Journal article
On immunotherapies and cancer vaccination protocols: A mathematical modelling approach
Journal of theoretical biology, Vol.259(4), pp.820-827
2009
Handle:
https://hdl.handle.net/2376/114771
PMID: 19446568
Abstract
In this paper we develop a new mathematical model of immunotherapy and cancer vaccination, focusing on the role of antigen presentation and co-stimulatory signaling pathways in cancer immunology. We investigate the effect of different cancer vaccination protocols on the well-documented phenomena of cancer dormancy and recurrence, and we provide a possible explanation of why adoptive (i.e. passive) immunotherapy protocols can sometimes actually promote tumour growth instead of inhibiting it (a phenomenon called immunostimulation), as opposed to active vaccination protocols based on tumour-antigen pulsed dendritic cells. Significantly, the results of our computational simulations suggest that elevated numbers of professional antigen presenting cells correlate well with prolonged time periods of cancer dormancy.
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Details
- Title
- On immunotherapies and cancer vaccination protocols: A mathematical modelling approach
- Creators
- Badal Joshi - Department of Mathematics, The Ohio State University, Columbus, OH 43210, USAXueying Wang - Department of Mathematics, The Ohio State University, Columbus, OH 43210, USASayanti Banerjee - Department of Mathematics, The Ohio State University, Columbus, OH 43210, USAHaiyan Tian - Department of Mathematics, The University of Southern Mississippi, Hattiesburg, MS 39406, USAAnastasios Matzavinos - Department of Mathematics, Iowa State University, Ames, IA 50011, USAMark A.J Chaplain - Department of Mathematics, University of Dundee, Dundee DD1 4HN, UK
- Publication Details
- Journal of theoretical biology, Vol.259(4), pp.820-827
- Academic Unit
- Mathematics and Statistics, Department of
- Publisher
- Elsevier Ltd
- Identifiers
- 99900547305201842
- Language
- English
- Resource Type
- Journal article