Journal article
Opening rates of DNA hairpins: experiment and model
Physical review. E, Statistical, nonlinear, and soft matter physics, Vol.76(1 Pt 1), pp.011909-011909
07/2007
Handle:
https://hdl.handle.net/2376/117690
PMID: 17677496
Abstract
We present single-molecule measurements of the opening rate of DNA hairpins under mechanical tension and compare with the results obtained from a reduced-degrees-of-freedom statistical mechanics model. We extract the apparent position of the transition state s and find that the model, with no fitting parameters, reproduces the experimental measurements surprisingly well. Our values for s are different from the ones obtained in previous experiments, where, however, the experimental conditions were different (different force fields, different salt concentrations). Thus it appears that the values of s measured for relatively short hairpins are strongly affected by these experimental conditions.
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Details
- Title
- Opening rates of DNA hairpins: experiment and model
- Creators
- Jeungphill Hanne - Department of Physics and Astronomy, University of California Los Angeles, Los Angeles, California 90095-1547, USAGiovanni ZocchiNikolaos K VoulgarakisAlan R BishopKim Ø Rasmussen
- Publication Details
- Physical review. E, Statistical, nonlinear, and soft matter physics, Vol.76(1 Pt 1), pp.011909-011909
- Academic Unit
- Mathematics and Statistics, Department of
- Publisher
- United States
- Identifiers
- 99900548347101842
- Language
- English
- Resource Type
- Journal article