Journal article
Opiate-like effects of electroconvulsive shock in rats: A differential effect of naloxone on nociceptive measures
Life sciences (1973), Vol.27(21), pp.1929-1938
1980
Handle:
https://hdl.handle.net/2376/113126
PMID: 7193791
Abstract
Electroconvulsive shock (ECS) in rats produced a generalized seizure which was followed by an opiate-like catalepsy and an increase in hot-plate escape latencies. Preinjection of naloxone, at doses of 3.0 and 10.0 mg/Kg, significantly diminished the ECS-induced increase in hot-plate latencies. Paradoxically, simultaneous measurement of tail-flick latencies in these same rats demonstrated opiate-
agonist
effects of naloxone. The cataleptic effects of ECS were demonstrated to be opiate-like by evaluating righting reflexes, grid responses, and haloperidol effects. Colonic temperatures were also measured in all animals. These data, collectively discussed relative to affective and reflexive components of nociceptive behaviors, support the hypothesis that selective endorphin systems are activated by ECS. Moreover, these observations suggest consideration of a role for endorphin systems in the therapeutic mechanisms of electroconvulsive therapy (ECT) in man.
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Details
- Title
- Opiate-like effects of electroconvulsive shock in rats: A differential effect of naloxone on nociceptive measures
- Creators
- John W HoladayGregory Lucas Belenky
- Publication Details
- Life sciences (1973), Vol.27(21), pp.1929-1938
- Publisher
- Elsevier Inc
- Identifiers
- 99900548305901842
- Language
- English
- Resource Type
- Journal article