Journal article
Opiate-like electroencephalographic and behavioral effects of electroconvulsive shock in rats
European journal of pharmacology, Vol.76(2), pp.121-128
1981
Handle:
https://hdl.handle.net/2376/113628
PMID: 7333352
Abstract
Rats were studies (a) after a single transauricular electroshock (acute ECS) and (b) following 10 consecutive once-daily shocks (chronic ECS). ECS produced a generalized convulsion marked by a polyspike EEG seizure. The seizure was followed by a period of postictal depression (PID) characterized by EEG high-voltage synchrony, EMG quietening, and an associated stuporous behavior in the rat. Acute ECS produced a maximal increase of 33±8 (S.E.) percent above control in the EEG voltage output during postictus, with the PID lasting 2 680±658 sec. Chronic ECS resulted in a significant enhancement of these acute responses. Pretreating rats with naloxone (0.3–10 mg/kg, s.c.) antagonized the postictal effects of acute ECS, but not of chronic ECS. These naloxone-sensitive postictal EEG and behavioral changes appear to reflect a release of endogenous opioid peptides during ictus, a finding consistent with the hypothesis that electroshock activates opioid systems.
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Details
- Title
- Opiate-like electroencephalographic and behavioral effects of electroconvulsive shock in rats
- Creators
- Frank C TortellaAlan Cowan - Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA 19140, U.S.AGregory L Belenky - Department of Medical Neurosciences, Walter Reed Army Institute of Research, Washington, DC 20012, U.S.AJohn W Holaday - Department of Medical Neurosciences, Walter Reed Army Institute of Research, Washington, DC 20012, U.S.A
- Publication Details
- European journal of pharmacology, Vol.76(2), pp.121-128
- Publisher
- Elsevier B.V
- Identifiers
- 99900547716601842
- Language
- English
- Resource Type
- Journal article