Journal article
Organismal regulation of XBP-1-mediated unfolded protein response during development and immune activation
EMBO reports, Vol.13(9), pp.855-860
09/2012
Handle:
https://hdl.handle.net/2376/104340
PMCID: PMC3432796
PMID: 22791024
Abstract
Neuronal receptor OCTR-1 is shown to control the XBP-1-mediated unfolded protein response in adult nematodes, but not during development. This controls ER homeostasis and immune activation, suggesting different requirements in these processes throughout development.
The increased demand on protein folding in the endoplasmic reticulum (ER) during bacterial infection activates the unfolded protein response (UPR). OCTR-1—a G protein-coupled catecholamine receptor expressed in neurons—suppresses innate immunity by downregulating a non-canonical UPR pathway and the p38 MAPK pathway. Here, we show that OCTR-1 also regulates the canonical UPR pathway, which is controlled by XBP-1, at the organismal level. Importantly, XBP-1 is not under OCTR-1 control during development, only at the adult stage. Our results indicate that the nervous system temporally controls the UPR pathway to maintain ER homeostasis during development and immune activation.
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Details
- Title
- Organismal regulation of XBP-1-mediated unfolded protein response during development and immune activation
- Creators
- Jingru Sun - , Durham, North Carolina 27710Yiyong Liu - , Durham, North Carolina 27710Alejandro Aballay - , Durham, North Carolina 27710
- Publication Details
- EMBO reports, Vol.13(9), pp.855-860
- Academic Unit
- Biomedical Sciences, Department of
- Publisher
- Nature Publishing Group
- Identifiers
- 99900547094001842
- Language
- English
- Resource Type
- Journal article