Journal article
Orientation independence of single-vacancy and single-ion permeability ratios
Biophysical journal, Vol.69(1), pp.84-93
07/1995
Handle:
https://hdl.handle.net/2376/105447
PMCID: PMC1236227
PMID: 7669913
Abstract
Single-vacancy models have been proposed as open channel permeation mechanisms for K+ channels. Single-ion models have been used to describe permeation through Na+ channels. This paper demonstrates that these models have a distinctive symmetry property. Their permeability ratios, measured under biionic conditions, are independent of channel orientation when the reversal potential is zero. This symmetry is a property of general m-site single-vacancy channels, m-site shaking-stack channels, as well as m-site single-ion channels. An experimental finding that the permeability ratios of a channel did not have this symmetry would provide evidence that a single-vacancy or single-ion model is an incorrect or incomplete description of permeation.
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Details
- Title
- Orientation independence of single-vacancy and single-ion permeability ratios
- Creators
- P McGill - Department of Pure and Applied Mathematics, Washington State University, Pullman 99164, USAM F Schumaker
- Publication Details
- Biophysical journal, Vol.69(1), pp.84-93
- Academic Unit
- Mathematics and Statistics, Department of
- Publisher
- United States
- Identifiers
- 99900546933301842
- Language
- English
- Resource Type
- Journal article