Journal article
Overview of the Second International Workshop to define swine cluster of differentiation (CD) antigens
Veterinary immunology and immunopathology, Vol.60(3), pp.207-228
1998
Handle:
https://hdl.handle.net/2376/116810
PMID: 9589560
Abstract
The aim of the Second International Swine Cluster of Differentiation (CD) Workshop, supported by the Veterinary Immunology Committee (VIC) of the International Union of Immunological Societies (IUIS), was to standardize the assignment of monoclonal antibodies (mAb) reactive with porcine leukocyte differentiation antigens and to define new antibody clusters. At the summary meeting of the workshop in July, 1995, revisions in the existing nomenclature for Swine CD were approved, so that the rules are now in accord with those for human and ruminant CD. Swine CD numbers will now be given to clusters of mAb to swine orthologues of human CD molecules when homology is proven by (1) suitable tissue distribution and lymphoid cell subset expression, (2) appropriate molecular mass of the antigen recognized by the mAbs, and (3) reactivity of mAbs with the cloned swine gene products, or cross-reactivity of the mAb on the human gene products. In some cases, this reactivity would not be fully proven, mainly due to the lack of cloned gene products; for these CD antigens, the respective clusters will be assigned by the prefix `w' which will lead to `wCD' antigens. As a result of the Second International Swine CD Workshop the assignment of 16 mAb to existing CD groups (CD2a, CD4a, CD5a, wCD6, wCD8, CD14, CD18a, wCD21, wCD25) was confirmed, and 2 mAb to existing swine workshop clusters (SWC). More importantly, for the work on the porcine immune system, was the definition of 5 new swine CD antigens, namely CD3 (recognized by 6 new mAb and 3 epitopes), CD16 (1 new mAb), wCD29 (2 mAb), CD45RA (3 mAb) and CD45RC (1 new mAb). Finally, the demarcation of two new SWC molecules in swine, SWC8 (2 mAb) and SWC9 (2 mAb) was confirmed.
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Details
- Title
- Overview of the Second International Workshop to define swine cluster of differentiation (CD) antigens
- Creators
- A Saalmüller - Federal Research Centre for Virus Diseases of Animals, Tübingen, GermanyT Pauly - Federal Research Centre for Virus Diseases of Animals, Tübingen, GermanyJ.K Lunney - USDA ARS, Immunology and Disease Resistance Laboratory, Beltsville, MD, USAPat Boyd - USDA ARS, Immunology and Disease Resistance Laboratory, Beltsville, MD, USAB Aasted - Department Veterinary Virology and Immunology, Royal Veterinary University, Frederiksberg C, DenmarkD.H Sachs - Transplantation Biology Research Center, Massachusetts General Hospital, Charlestown, MA, USAS Arn - Transplantation Biology Research Center, Massachusetts General Hospital, Charlestown, MA, USAA Bianchi - Central Veterinary Institute CDI, Lelystaad, NetherlandsR.M Binns - AFRC Institute for Animal Physiology, Babraham, Cambridge, UKS Licence - AFRC Institute for Animal Physiology, Babraham, Cambridge, UKA Whyte - AFRC Institute for Animal Physiology, Babraham, Cambridge, UKF Blecha - Department of Anatomy and Physiology, Kansas State University, Manhattan, KS, USAZ Chen - Diagn. and Clin. Research, Pharmingen, 10975 Torreyana Road, San Diego, CA, USAR.M Chu - Pig Research Institute Taiwan, Miaoli, Chunan, TaiwanW.C Davis - Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA, USAS Denham - IAH Pirbright Laboratory, Pirbright, Woking, UKH Yang - IAH Pirbright Laboratory, Pirbright, Woking, UKT Whittall - IAH Pirbright Laboratory, Pirbright, Woking, UKR.M Parkhouse - IAH Pirbright Laboratory, Pirbright, Woking, UKJ Dominguez - CISA-INIA, Valdeolmos, Madrid, SpainA Ezquerra - CISA-INIA, Valdeolmos, Madrid, SpainF Alonso - CISA-INIA, Valdeolmos, Madrid, SpainG Horstick - Uniklinik Mainz, II. Medizinische Klinik, Langerbeckstr., Mainz, GermanyC Howard - BBSRC, IAH, Compton, Newbury, Berkshire RG20 7NN, UKP Sopp - BBSRC, IAH, Compton, Newbury, Berkshire RG20 7NN, UKY.B Kim - Department of Microbiology and Immunology, Finch University of Health Sciences, The Chicago Medical School, North Chicago, IL, USAJ Lipp - VIRCC, Laboratory of Transplantation Immunology, Brunner Strasse 59, Vienna, AustriaC Mackay - Leukosite INC, 800 Huntington Ave., Boston, MA, 02115, USAA Magyar - Department of Immunology, University of Eötvös, Göd, Javorka S.u.14., HungaryK McCullough - Institut für Viruskrankheiten und Immunprophylaxe, 3147 Mittelhäusern, SwitzerlandA Arriens - Institut für Viruskrankheiten und Immunprophylaxe, 3147 Mittelhäusern, SwitzerlandA Summerfield - Institut für Viruskrankheiten und Immunprophylaxe, 3147 Mittelhäusern, SwitzerlandM Murtaugh - Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Minnesota, St.Paul, MN, USAJ Nielsen - State Veterinary Institute for Virus Research, Lindholm, 4771 Kalvehave, DenmarkB Novikov - All-Russian Research Institute of Veterinary Virology and Microbiology, Pokrov, Vladimizskaya obl., Russian FederationM.D Pescovitz - Indiana University, Department of Surgery, University Hospital, Indianapolis, IN, USAH.J Schuberth - Immunologie der Tierärztl. Hochschule, Bischofsholer Damm 15, Hannover, GermanyW Leibold - Immunologie der Tierärztl. Hochschule, Bischofsholer Damm 15, Hannover, GermanyC Schütt - Institut für Immunol. und Transfusionsmed., EMA-Universität, Greifswald, GermanyM Shimizu - National Institute for Animal Health, Ibaraki 305, JapanC Stokes - Department Veterinary Medicine, University of Bristol, School of Medicine, Langford, Bristol, UKK Haverson - Department Veterinary Medicine, University of Bristol, School of Medicine, Langford, Bristol, UKM Bailey - Department Veterinary Medicine, University of Bristol, School of Medicine, Langford, Bristol, UKH Tlaskalova - Czech Academy of Science, Institute of Microbiology, Prague, Czech RepublicI Trebichavsky - Gnotobiological Laboratory, Novy Hradek, Novy Hradek, Czech RepublicI Valpotic - Department of Biology, Veterinary Faculty, University of Zagreb, Zagreb, CroatiaJ Walker - Centre for Animal Biotechnology, School of Veterinary Science, University of Melbourne, Parkville, Victoria 3052, AustraliaR Lee - Centre for Animal Biotechnology, School of Veterinary Science, University of Melbourne, Parkville, Victoria 3052, AustraliaF Zuckermann - Univ. of Illinois, Department of Veterinary Pathobiology, Urbana, IL, USA
- Publication Details
- Veterinary immunology and immunopathology, Vol.60(3), pp.207-228
- Academic Unit
- Medical Education and Clinical Science, Department of; Veterinary Microbiology and Pathology, Department of
- Publisher
- Elsevier B.V
- Identifiers
- 99900548019601842
- Language
- English
- Resource Type
- Journal article