Journal article
Ovine progressive pneumonia provirus levels are unaffected by the prion 171R allele in an Idaho sheep flock
Genetics selection evolution (Paris), Vol.41(1), pp.17-17
2009
Handle:
https://hdl.handle.net/2376/108845
PMCID: PMC3225825
PMID: 19284685
Abstract
Selective breeding of sheep for arginine (
R
) at prion gene (
PRNP
) codon 171 confers resistance to classical scrapie. However, other effects of
171R
selection are uncertain. Ovine progressive pneumonia/Maedi-Visna virus (OPPV) may infect up to 66% of a flock thus any affect of
171R
selection on OPPV susceptibility or disease progression could have major impact on the sheep industry. Hypotheses that the
PRNP 171R
allele is 1) associated with the presence of OPPV provirus and 2) associated with higher provirus levels were tested in an Idaho ewe flock. OPPV provirus was found in 226 of 358 ewes by quantitative PCR. The frequency of ewes with detectable provirus did not differ significantly among the
171QQ
,
171QR
, and
171RR
genotypes (p > 0.05). Also, OPPV provirus levels in infected ewes were not significantly different among codon 171 genotypes (p > 0.05). These results show that, in the flock examined, the presence of OPPV provirus and provirus levels are not related to the
PRNP 171R
allele. Therefore, a genetic approach to scrapie control is not expected to increase or decrease the number of OPPV infected sheep or the progression of disease. This study provides further support to the adoption of
PRNP 171R
selection as a scrapie control measure.
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Details
- Title
- Ovine progressive pneumonia provirus levels are unaffected by the prion 171R allele in an Idaho sheep flock
- Creators
- Robert D Harrington - Animal Disease Research Unit, Agricultural Research Service, US Department of Agriculture, Pullman, WA 99164-6630, USALynn M Herrmann-Hoesing - Animal Disease Research Unit, Agricultural Research Service, US Department of Agriculture, Pullman, WA 99164-6630, USAStephen N White - Animal Disease Research Unit, Agricultural Research Service, US Department of Agriculture, Pullman, WA 99164-6630, USAKatherine I O'Rourke - Animal Disease Research Unit, Agricultural Research Service, US Department of Agriculture, Pullman, WA 99164-6630, USADonald P Knowles - Animal Disease Research Unit, Agricultural Research Service, US Department of Agriculture, Pullman, WA 99164-6630, USA
- Publication Details
- Genetics selection evolution (Paris), Vol.41(1), pp.17-17
- Academic Unit
- Veterinary Microbiology and Pathology, Department of
- Publisher
- BioMed Central
- Identifiers
- 99900547352401842
- Language
- English
- Resource Type
- Journal article