Journal article
Ovine progressive pneumonia provirus levels associate with breed and Ovar-DRB1
Immunogenetics (New York), Vol.60(12), pp.749-758
12/2008
Handle:
https://hdl.handle.net/2376/106934
PMID: 18797863
Abstract
Previous studies initiated defining the role of host genetics in influencing the outcome of exposure to ovine progressive pneumonia virus. However, specific genes influencing host control of virus replication and disease progression have not been identified. This study, using 383 ewes of the Columbia, Polypay, and Rambouillet breeds, tested the hypothesis that host control of OPPV as measured by provirus levels in the peripheral blood associates with certain breeds and MHC class II Ovis aries (Ovar)-DRB1 expressed alleles. Rambouillet ewes were less likely to have measurable provirus levels as compared to Columbia ewes at ages 5 and 6 (P value < 0.02), and they exhibited lower provirus levels when compared to both Columbia and Polypay ewes of the same ages (P value < 0.05). The presence of DRB1*0403- or DRB1*07012-expressed alleles were significantly associated (P value = 0.019 and 0.0002, respectively) with lower OPP provirus levels but only were only found in 11% of the ewe flock. Analysis of each segregating amino acid in the β1 domain of DR β-chain revealed that amino acids Y31, T32, N37, T51, Q60, or N74 significantly associated (P value range = 0.0003–0.018) with lower OPP provirus levels, whereas amino acids H32, A38, or I67 associated (P value range = 0.013–0.043) with higher OPP provirus levels. These results suggest that Ovar-DRB1 contributes as one host genetic factor that controls OPP provirus levels, but does not fully account for the breed-specific OPP proviral differences.
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Details
- Title
- Ovine progressive pneumonia provirus levels associate with breed and Ovar-DRB1
- Creators
- Lynn Herrmann-Hoesing - 3003 ADBF, Washington State University Pullman WA 99164-6630 USAStephen White - Department of Veterinary Microbiology and Pathology Washington State University Pullman WA 99164-7040 USAMichelle Mousel - U.S. Department of Agriculture U.S. Sheep Experiment Station, Agricultural Research Service Dubois ID 83423 USAGregory Lewis - U.S. Department of Agriculture U.S. Sheep Experiment Station, Agricultural Research Service Dubois ID 83423 USADonald Knowles - Department of Veterinary Microbiology and Pathology Washington State University Pullman WA 99164-7040 USA
- Publication Details
- Immunogenetics (New York), Vol.60(12), pp.749-758
- Academic Unit
- Veterinary Microbiology and Pathology, Department of; Paul G. Allen School for Global Animal Health
- Publisher
- Springer-Verlag; Berlin/Heidelberg
- Identifiers
- 99900546829101842
- Language
- English
- Resource Type
- Journal article