Journal article
Parameter estimation in a crossbridge muscle model
Journal of biomechanical engineering, Vol.125(1), pp.132-140
02/2003
Handle:
https://hdl.handle.net/2376/105024
PMID: 12661207
Abstract
Models of muscle crossbridge dynamics have great potential for understanding muscle contraction and having a wide range of application. However, the estimation of many model parameters, most of which are difficult to measure, limits their applicability. This study developed a method of estimating parameters in the Distribution Moment crossbridge model from measurements of force-length and force-velocity relationships in cat soleus single muscle fibers. Analysis of the parameter estimates showed that the detachment rate parameters had more uncertainty than the attachment rate parameter, which could reflect physiological variations in the contractile protein content and in the response of muscle to lengthenings.
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Details
- Title
- Parameter estimation in a crossbridge muscle model
- Creators
- David C Lin - Department of Biological Systems Engineering, Washington State University, P.O. Box 646120, Pullman, WA 99164-6120, USA. davidlin@wsu.eduT Richard Nichols
- Publication Details
- Journal of biomechanical engineering, Vol.125(1), pp.132-140
- Academic Unit
- Chemical Engineering and Bioengineering, School of
- Publisher
- United States
- Grant note
- F32 NS10688-01 / NINDS NIH HHS NS20855 / NINDS NIH HHS HD32571-03 / NICHD NIH HHS
- Identifiers
- 99900546980401842
- Language
- English
- Resource Type
- Journal article