Journal article
Perfluorocarbon-facilitated CNS oxygen toxicity in rats: Reversal by edaravone
Brain research, Vol.1471, pp.56-65
08/30/2012
Handle:
https://hdl.handle.net/2376/104417
PMID: 22781141
Abstract
Perfluorocarbon (PFC) has been hypothesized to potentially increase the risk of central nervous system oxygen toxicity (CNS-OT) under hyperbaric oxygen (HBO) conditions. However, little is known about the effects, mechanism and prevention of PFC-facilitated CNS-OT. A rat model of CNS-OT was used to evaluate the effects of intravenously-administered PFC emulsion. The electroencephalogram (EEG) was recorded during treatment with HBO2 at 6.0 ATA in the presence and absence of PFC. Concentrations of malondialdehyde (MDA), nitric oxide (NO) and hydrogen peroxide (H2O2) in the brain cortex and hippocampus were quantified. Changes in the activities of superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT) and NO synthase (NOS) in the brain cortex and hippocampus were also determined. Edaravone, a potent antioxidant, was used to prevent PFC-facilitated CNS-OT. The results showed that after PFC administration, the latency to first electrical discharge in EEG was significantly shortened; MDA, H2O2, NO levels and NOS activity increased; and SOD, GPx and CAT activities decreased. Edaravone effectively protected against CNS-OT and the adverse effects of PFC. The results clearly demonstrate that PFC administered before HBO2 would promote the occurrence of CNS-OT, and edaravone could serve as a promising chemoprophylactic agent to prevent CNS-OT.
► We evaluate the effects of perfluorocarbon and edaravone on central nervous system oxygen toxicity. ► Concentrations of malondialdehyde, nitric oxide and hydrogen peroxide in the brain were quantified. ► Changes in the activities of antioxidases and NO synthase in the brain were determined.
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Details
- Title
- Perfluorocarbon-facilitated CNS oxygen toxicity in rats: Reversal by edaravone
- Creators
- Shulin Liu - Department of Diving Medicine, the Second Military Medical University, Shanghai 200433, P.R. ChinaRunping Li - Department of Diving Medicine, the Second Military Medical University, Shanghai 200433, P.R. ChinaXiaoxiao Ni - Department of Diving Medicine, the Second Military Medical University, Shanghai 200433, P.R. ChinaZhiyu Cai - Department of Diving Medicine, the Second Military Medical University, Shanghai 200433, P.R. ChinaRongjia Zhang - Department of Diving Medicine, the Second Military Medical University, Shanghai 200433, P.R. ChinaXuejun Sun - Department of Diving Medicine, the Second Military Medical University, Shanghai 200433, P.R. ChinaRaymond M Quock - Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, USAWeigang Xu - Department of Diving Medicine, the Second Military Medical University, Shanghai 200433, P.R. China
- Publication Details
- Brain research, Vol.1471, pp.56-65
- Academic Unit
- Psychology, Department of
- Publisher
- Elsevier B.V
- Identifiers
- 99900546742701842
- Language
- English
- Resource Type
- Journal article