Journal article
Performance impairment consequent to sleep loss: determinants of resistance and susceptibility
Current opinion in pulmonary medicine, Vol.15(6), pp.559-564
11/2009
Handle:
https://hdl.handle.net/2376/104173
PMID: 19713847
Abstract
Five years ago, it was first demonstrated that there are considerable, stable individual differences in performance impairment due to sleep deprivation. The discovery of this new phenotype, which has been labeled 'trototype', led to a surge of research activity aiming to identify predictors.
Genes involved in the adenosinergic and circadian regulation of sleep have been identified as candidate predictors of individuals' resistance or susceptibility to performance impairment resulting from sleep deprivation. Furthermore, brain regions potentially involved in the expression of individual differences in vulnerability to sleep loss have been found. This research has provided new insights into the mechanisms underlying sleep/wake regulation and responses to loss of sleep. To date, however, it remains unknown how much of the phenotypic variability is explained by any of the putative predictors of trototype.
The existence of substantial, phenotypic individual differences in performance impairment consequent to sleep loss has important implications for fatigue risk management in operational settings and for the symptomology and treatment of sleep disorders, putting a premium on the discovery of reliable predictors.
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Details
- Title
- Performance impairment consequent to sleep loss: determinants of resistance and susceptibility
- Creators
- Andrew C King - Sleep and Performance Research Center, Washington State University, Spokane, Washington 99210-1495, USAGregory BelenkyHans P A Van Dongen
- Publication Details
- Current opinion in pulmonary medicine, Vol.15(6), pp.559-564
- Academic Unit
- Medical Education and Clinical Science, Department of
- Publisher
- United States
- Identifiers
- 99900546663501842
- Language
- English
- Resource Type
- Journal article