Journal article
Periaqueductal gray stimulation produces a spinally mediated, opioid antinociception for the inflamed hindpaw of the rat
Brain research, Vol.545(1), pp.17-23
1991
Handle:
https://hdl.handle.net/2376/113470
PMID: 1860042
Abstract
The objective of the present study was to characterize stimulation-produced antinociception from the periaqueductal gray matter (PAG) in rats with unilateral hindlimb inflammation induced by an intraplantar injection of Freund's complete adjuvant. Rats were chronically implanted with a bipolar stimulating electrode in the PAG. Nociception was assessed using a paw pressure test. Prior to inflammation, PAG stimulation significantly increased paw pressure thershold in both paws compared to non-stimulated controls. Following inflammation, PAG stimulation inhibited nociception in the inflamed, but not the non-inflamed paw. Systemic administration of naloxone blocked antinociception from ventral, but not dorsal PAG stimulation sites. Intrathecal, but not subcutaneous, administration of quaternary naltrexone completely blocked stimulation-produced antinociception from the PAG. The known increased levels of endogenous opioids occurring in the spinal cord ipsilateral to the site of inflammation suggest a mechanism for the selective antinociceptive effect of ventral PAG stimulation seen for the inflamed paw.
Metrics
6 Record Views
Details
- Title
- Periaqueductal gray stimulation produces a spinally mediated, opioid antinociception for the inflamed hindpaw of the rat
- Creators
- Michael M Morgan - Department of Psychology, University of California, Los Angeles, CA 90024-1563 U.S.AMichael S Gold - Department of Psychology, University of California, Los Angeles, CA 90024-1563 U.S.AJohn C Liebeskind - Department of Psychology, University of California, Los Angeles, CA 90024-1563 U.S.AChristoph Stein - Department of Anesthesiology, Ludwig-Maximilians-Universita¨t, Klinikum Grosshadern, Mu¨nchen F.R.G
- Publication Details
- Brain research, Vol.545(1), pp.17-23
- Academic Unit
- Psychology, Department of
- Publisher
- Elsevier B.V
- Identifiers
- 99900547982001842
- Language
- English
- Resource Type
- Journal article