Journal article
Pharmacology, efficacy, and safety of linagliptin for the treatment of type 2 diabetes mellitus
The Annals of pharmacotherapy, Vol.46(3), pp.358-367
03/2012
Handle:
https://hdl.handle.net/2376/114159
PMID: 22318932
Abstract
To review the pharmacology, pharmacokinetics, and clinical efficacy and safety of linagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor recently approved in the US for use as a treatment for type 2 diabetes mellitus.
English-language articles in the PubMed database to October 2011 (selected using the search terms linagliptin, alogliptin, sitagliptin, saxagliptin, vildagliptin, and pharmacokinetics, pharmacodynamics, or diabetes) were identified for review. Reference lists from identified articles were reviewed for additional references of interest. Abstracts published at relevant meetings were also evaluated, and information was obtained from the manufacturer.
Publications reporting the pharmacology, pharmacokinetics, and clinical efficacy and safety of linagliptin were reviewed.
Linagliptin therapy results in clinically meaningful reductions in hemoglobin A(1c), as well as fasting and postprandial plasma glucose levels in patients with type 2 diabetes mellitus. It contrasts with other agents in its class by not requiring dosage adjustment in patients with renal or hepatic impairment. Oral doses of linagliptin 5 mg once daily have been shown to be clinically effective, well tolerated, and weight-neutral. An increased rate of hypoglycemia when linagliptin was used in combination with an insulin secretagogue compared to placebo was noted in clinical trials.
Linagliptin provides an additional therapeutic option for type 2 diabetes mellitus and, in contrast to other agents in the DPP-4 class, can be used without dose adjustment in patients with any degree of declining renal function.
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Details
- Title
- Pharmacology, efficacy, and safety of linagliptin for the treatment of type 2 diabetes mellitus
- Creators
- Joshua J Neumiller - College of Pharmacy, Washington State University, Spokane, WA, USA. jneumiller@wsu.edu
- Publication Details
- The Annals of pharmacotherapy, Vol.46(3), pp.358-367
- Academic Unit
- Pharmacotherapy, Department of
- Publisher
- United States
- Identifiers
- 99900547323601842
- Language
- English
- Resource Type
- Journal article