Journal article
Physical activity and differential methylation of breast cancer genes assayed from saliva: a preliminary investigation
Annals of behavioral medicine, Vol.45(1), pp.89-98
02/2013
Handle:
https://hdl.handle.net/2376/110900
PMCID: PMC3548059
PMID: 23054940
Abstract
Individuals who exercise are at lower risk for breast cancer and have better post-diagnosis outcomes. The biological mechanisms behind this association are unclear, but DNA methylation has been suggested.
We developed a composite measure of DNA methylation across 45 CpG sites on genes selected a priori. We examined the association of this measure to self-reported physical activity and objectively measured cardiovascular fitness in a sample of healthy nonsmoking adults (n = 64) in an exercise promotion intervention.
Individuals who were more physically fit and who exercised more minutes per week had lower levels of DNA methylation. Those who increased their minutes of physical activity over 12 months experienced decreases in DNA methylation.
DNA methylation may be a mechanism linking exercise and cancer incidence and could serve as a biomarker for behavioral intervention trials. Studies with larger samples, objectively measured exercise, and more cancer-related markers are needed.
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Details
- Title
- Physical activity and differential methylation of breast cancer genes assayed from saliva: a preliminary investigation
- Creators
- Angela D Bryan - Department of Psychology and Neuroscience, University of Colorado Boulder, 80309-0345, USA. angela.bryan@colorado.eduRenee E MagnanAnn E Caldwell HooperNicole HarlaarKent E Hutchison
- Publication Details
- Annals of behavioral medicine, Vol.45(1), pp.89-98
- Academic Unit
- Psychology, Department of
- Publisher
- England
- Grant note
- R01 CA109858 / NCI NIH HHS M01-RR00051 / NCRR NIH HHS M01 RR000051 / NCRR NIH HHS
- Identifiers
- 99900547032801842
- Language
- English
- Resource Type
- Journal article