Physiological markers of local sleep

David M Rector; Jennifer L Schei; Hans P A Van Dongen; Gregory Belenky; James M Krueger

doi:10.1111/j.1460-9568.2009.06717.x

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Physiological markers of local sleep

David M Rector, Jennifer L Schei, Hans P A Van Dongen, Gregory Belenky and James M Krueger

The European journal of neuroscience, Vol.29(9), pp.1771-1778

05/2009

DOI: https://doi.org/10.1111/j.1460-9568.2009.06717.x

Handle:

https://hdl.handle.net/2376/114221

PMCID: PMC2688439

PMID: 19473232

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Abstract

Animals

Cerebrovascular Circulation - physiology

Humans

Evoked Potentials

Blood Volume - physiology

Sleep - physiology

Brain - physiology

Neural Pathways - physiology

Oxygen - blood

Substantial evidence suggests that brain regions that have been disproportionately used during waking will require a greater intensity and/or duration of subsequent sleep. For example, rats use their whiskers in the dark and their eyes during the light, and this is manifested as a greater magnitude of electroencephalogram (EEG) slow-wave activity in the somatosensory and visual cortex during sleep in the corresponding light and dark periods respectively. The parsimonious interpretation of such findings is that sleep is distributed across local brain regions and is use-dependent. The fundamental properties of sleep can also be experimentally defined locally at the level of small neural assemblies such as cortical columns. In this view, sleep is orchestrated, but not fundamentally driven, by central mechanisms. We explore two physiological markers of local, use-dependent sleep, namely, an electrical marker apparent as a change in the size and shape of an electrical evoked response, and a metabolic marker evident as an evoked change in blood volume and oxygenation delivered to activated tissue. Both markers, applied to cortical columns, provide a means to investigate physiological mechanisms for the distributed homeostatic regulation of sleep, and may yield new insights into the consequences of sleep loss and sleep pathologies on waking brain function.

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Details

Title: Physiological markers of local sleep
Creators: David M Rector - Sleep and Performance Research Center and Program in Neuroscience, Washington State University, Spokane, WA 99210-1495, USA. drector@wsu.edu
Jennifer L Schei
Hans P A Van Dongen
Gregory Belenky
James M Krueger
Publication Details: The European journal of neuroscience, Vol.29(9), pp.1771-1778
Academic Unit: Medical Education and Clinical Science, Department of; Integrative Physiology and Neuroscience, Department of
Publisher: France
Grant note: NS 31453 / NINDS NIH HHS MH 60263 / NIMH NIH HHS R01 MH071830-04 / NIMH NIH HHS R01 NS031453-16 / NINDS NIH HHS R01 MH071830 / NIMH NIH HHS R01 NS025378-22 / NINDS NIH HHS R01 NS031453 / NINDS NIH HHS MH71830 / NIMH NIH HHS R01 NS031453-17 / NINDS NIH HHS R01 MH060263-08 / NIMH NIH HHS R01 NS025378-21 / NINDS NIH HHS R01 NS025378 / NINDS NIH HHS R01 MH060263 / NIMH NIH HHS NS 25378 / NINDS NIH HHS
Identifiers: 99900547468601842
Language: English
Resource Type: Journal article