Journal article
Platelet activating factor and its metabolite promote sleep in rabbits
Neuroscience letters, Vol.394(3), pp.233-238
2006
Handle:
https://hdl.handle.net/2376/113865
PMID: 16263215
Abstract
Platelet activating factor (PAF) is a key inflammatory mediator. PAF and its receptor are found in brain and PAF affects or is affected by the production of sleep promoting cytokines such as interleukin-1. PAF also interacts with several other sleep-regulatory substances such as nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3, nitric oxide, prostaglandins, and prolactin. We thus hypothesized that PAF would increase sleep. In these experiments, each rabbit received an injection of 25
μl of 2% DMSO to obtain control values, and on a separate day received PAF or lyso-PAF, a metabolite of PAF. Ten, 100 and 500
nmol for each substance was injected intracerebroventricularly. Both PAF and lyso-PAF enhanced non-rapid eye movement (NREM) sleep but not REM sleep. Lyso-PAF, but not PAF, induced hyperthermia. Results are consistent with the hypothesis that the brain cytokine network is involved in physiological sleep regulation.
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Details
- Title
- Platelet activating factor and its metabolite promote sleep in rabbits
- Creators
- Tetsuya Kushikata - Department of Anesthesiology, University of Hirosaki School of Medicine, Hirosaki 036-8506, JapanJidong Fang - Department of Psychiatry, College of Medicine, The Pennsylvania State University, Hershey, PA 17033, USAJames M Krueger - Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, Pullman, WA 99164-6520, USA
- Publication Details
- Neuroscience letters, Vol.394(3), pp.233-238
- Academic Unit
- Integrative Physiology and Neuroscience, Department of
- Publisher
- Elsevier Ireland Ltd
- Identifiers
- 99900547624301842
- Language
- English
- Resource Type
- Journal article