Journal article
Polydopamine-Capped Bimetallic AuPt Hydrogels Enable Robust Biosensor for Organophosphorus Pesticide Detection
Small (Weinheim an der Bergstrasse, Germany), Vol.15(17), pp.1-8
04/01/2019
PMID: 30938485
Abstract
Noble metal hydrogels/aerogels with macroscopic nanoassemblies characterized by ultralow density, profuse continuous porosity, and extremely large surface area have gained abundant interest due to not only their tunable physicochemical properties, but also promising applications in catalysis and sensing. Coupling the increased reaction temperature with dopamine-induced effect, herein, a one-step synthetic approach with accelerated gelation kinetics is reported for the synthesis of polydopamine-capped bimetallic AuPt hydrogels. 3D porous nanowire networks with surface functionalization of polydopamine make them a promising biocompatible microenvironment for immobilizing acetylcholinesterase (AChE) and constructing enzyme-based biosensors for sensitive detection of organophosphorus compounds. Taking advantage of their favorable structure and composition, the optimized product exhibits superior electrochemical activity toward thiocholine produced by AChE-catalyzed hydrolysis of acetylthiocholine. Based on the inhibition of organophosphorus pesticide on the enzymatic activity of AChE, the inhibition mode for the detection of paraoxon-ethyl is established, displaying linear regions over the range of 0.5-1000 ng L-1 with a low detection limit of 0.185 ng L-1.
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Details
- Title
- Polydopamine-Capped Bimetallic AuPt Hydrogels Enable Robust Biosensor for Organophosphorus Pesticide Detection
- Creators
- Yu Wu - Central China Normal UniversityLei Jiao - Central China Normal UniversityWeiqing Xu - Central China Normal UniversityWenling Gu - Central China Normal UniversityChengzhou Zhu - Central China Normal UniversityDan Du - Washington State UniversityYuehe Lin - Washington State University
- Publication Details
- Small (Weinheim an der Bergstrasse, Germany), Vol.15(17), pp.1-8
- Academic Unit
- School of Mechanical and Materials Engineering
- Publisher
- Wiley
- Number of pages
- 8
- Grant note
- Recruitment Program of Global Youth Experts of China B17019 / Program of Introducing Talents of Discipline to Universities of China (111 program) CCNU19QN066 / Fundamental Research Funds for the Central Universities
- Identifiers
- 99901227641601842
- Language
- English
- Resource Type
- Journal article