Journal article
Polymorphic Markers for the Arylsulfatase A Gene Reveal a Greatly Expanded Meiotic Map for the Human 22q Telomeric Region
Genomics (San Diego, Calif.), Vol.63(3), pp.430-432
02/01/2000
Handle:
https://hdl.handle.net/2376/116441
PMID: 10704291
Abstract
Two microsatellite markers, D22S1743 and D22S1744, were developed for the arylsulfatase A (ARSA) region of chromosome 22q. Linkage analysis for 171 families, using nine reference markers covering all of 22q, placed these new markers 2.0 Kosambi cM distal to D22S526, making them more distal than any microsatellite markers currently on the Généthon or Marshfield linkage maps. Recombination between proximal markers D22S270/D22S683 and D22S446/D22S311 exhibited increased rates of female meiotic recombination compared to male recombination (P < 0.01). In contrast, the region encompassing sJCW16, D22S526, D22S1743, and D22S1744 exhibited relatively greater recombination in males (1.1 cM for females and 7.5 cM for males; χ2; P < 0.005). These four distal markers lie in a region of hyperrecombination having a sex-averaged recombination ratio of between 8.3 (D22S1843/D22S1744) and 12 cM (sJCW16/D22S526) per megabase.
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Details
- Title
- Polymorphic Markers for the Arylsulfatase A Gene Reveal a Greatly Expanded Meiotic Map for the Human 22q Telomeric Region
- Creators
- Mark D Brennan - Department of Biochemistry and Molecular Biology, University of Louisville Medical School, Louisville, Kentucky, 40292Holly L Neibergs - Department of Biochemistry and Molecular Biology, University of Louisville Medical School, Louisville, Kentucky, 40292Kay Phillips - Department of Pediatrics, University of Louisville Medical School, Louisville, Kentucky, 40292Steve Moseley - Department of Biochemistry and Molecular Biology, University of Louisville Medical School, Louisville, Kentucky, 40292
- Publication Details
- Genomics (San Diego, Calif.), Vol.63(3), pp.430-432
- Academic Unit
- Animal Sciences, Department of
- Publisher
- Elsevier Inc
- Identifiers
- 99900547870301842
- Language
- English
- Resource Type
- Journal article