Journal article
Population genomic analyses of the chocolate tree, Theobroma cacao L., provide insights into its domestication process
Communications biology, Vol.1(1), pp.167-167
2018
Handle:
https://hdl.handle.net/2376/116067
PMCID: PMC6191438
PMID: 30345393
Abstract
Domestication has had a strong impact on the development of modern societies. We sequenced 200 genomes of the chocolate plant
L. to show for the first time to our knowledge that a single population, the Criollo population, underwent strong domestication ~3600 years ago (95% CI: 2481-13,806 years ago). We also show that during the process of domestication, there was strong selection for genes involved in the metabolism of the colored protectants anthocyanins and the stimulant theobromine, as well as disease resistance genes. Our analyses show that domesticated populations of
(Criollo) maintain a higher proportion of high-frequency deleterious mutations. We also show for the first time the negative consequences of the increased accumulation of deleterious mutations during domestication on the fitness of individuals (significant reduction in kilograms of beans per hectare per year as Criollo ancestry increases, as estimated from a GLM,
= 0.000425).
Metrics
8 Record Views
Details
- Title
- Population genomic analyses of the chocolate tree, Theobroma cacao L., provide insights into its domestication process
- Creators
- Omar E Cornejo - Department of Genetics, School of Medicine, Stanford University, 300 Pasteur Dr. Lane Bldg Room L331, Stanford, CA, 94305, USAMuh-Ching Yee - Stanford Functional Genomics Facility, Stanford, CA, 94305, USAVictor Dominguez - Department of Biology, Indiana University, 915 E. Third St, Bloomington, IN, 47405, USAMary Andrews - Department of Biology, Indiana University, 915 E. Third St, Bloomington, IN, 47405, USAAlexandra Sockell - Department of Genetics, School of Medicine, Stanford University, 300 Pasteur Dr. Lane Bldg Room L331, Stanford, CA, 94305, USAErika Strandberg - Biomedical Informatics Training Program, 1265 Welch Road, MSOB, X-215, MC 5479, Stanford, CA, 94305-5479, USADonald Livingstone, 3rd - United States Department of Agriculture-Agriculture Research Service, Subtropical Horticulture Research Station, 13601 Old Cutler Rd, Miami, FL, 33158, USAConrad Stack - Mars, Incorporated, 6885 Elm Street, McLean, VA, 22101, USAAlberto Romero - Mars, Incorporated, 6885 Elm Street, McLean, VA, 22101, USAPathmanathan Umaharan - Cocoa Research Centre, The University of the West Indies, St. Augustine, Trinidad and TobagoStefan Royaert - Mars, Incorporated, 6885 Elm Street, McLean, VA, 22101, USANilesh R Tawari - Computational and Systems Biology, Genome Institute of Singapore, 60 Biopolis Street, Genome, #02-01, Singapore, 138672, SingaporePauline Ng - Computational and Systems Biology, Genome Institute of Singapore, 60 Biopolis Street, Genome, #02-01, Singapore, 138672, SingaporeOsman Gutierrez - SHRS, USDS-ARS, 13601 Old Cutler Road, Miami, FL, 33158, USAWilbert Phillips - Programa de Mejoramiento de Cacao, CATIE, 7170, Turrialba, Costa RicaKeithanne Mockaitis - Pervasive Technology Institute, Indiana University, 2709 E. 10th St., Bloomington, IN, 47408, USACarlos D Bustamante - Department of Genetics, School of Medicine, Stanford University, 300 Pasteur Dr. Lane Bldg Room L331, Stanford, CA, 94305, USAJuan C Motamayor - Mars, Incorporated, 6885 Elm Street, McLean, VA, 22101, USA. juancarlos.motamayor@gmail.com
- Publication Details
- Communications biology, Vol.1(1), pp.167-167
- Academic Unit
- Biological Sciences, School of
- Publisher
- England
- Identifiers
- 99900547957101842
- Language
- English
- Resource Type
- Journal article