Journal article
Possible involvement of nitric oxide in chlordiazepoxide-induced anxiolysis in mice
Life sciences (1973), Vol.51(25), pp.PL255-PL260
1992
Handle:
https://hdl.handle.net/2376/104022
PMID: 1280754
Abstract
Mice challenged with the anxiolytic benzodiazepine chlordiazepoxide exhibited significant increases in the percent of total entries into and percent of total time spent on open arms of an elevated plus maze. Systemic pretreatment with the nitric oxide synthase-inhibitor L-N
G-nitro arginine (L-NOARG) antagonized these effects of chlordiazepoxide. This inhibitory effect of L-NOARG was stereospecifically and completely reversed by intracerebroventricular administration of L-arginine but not D-arginine. These findings suggest a possible role of nitric oxide in the anxiolytic effect of chlordiazepoxide in the elevated plus maze.
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Details
- Title
- Possible involvement of nitric oxide in chlordiazepoxide-induced anxiolysis in mice
- Creators
- Raymond M QuockElizabeth Nguyen
- Publication Details
- Life sciences (1973), Vol.51(25), pp.PL255-PL260
- Academic Unit
- Psychology, Department of
- Publisher
- Elsevier Inc
- Identifiers
- 99900546514701842
- Language
- English
- Resource Type
- Journal article