Journal article
Pre-melting dynamics of DNA and its relation to specific functions
Journal of physics. Condensed matter, Vol.21(3), pp.034107-034107 (8)
01/21/2009
Handle:
https://hdl.handle.net/2376/107772
PMID: 21817252
Abstract
We discuss connections between the nonlinear dynamics of double-stranded DNA, experimental findings, and specific DNA functions. We begin by discussing how thermally induced localized openings (bubbles) of the DNA double strand are important for interpreting dynamic force spectroscopy data. Then we demonstrate a correlation between a sequence-dependent propensity for pre-melting bubble formation and transcription initiation and other regulatory effects in viral DNA. Finally, we discuss the possibility of a connection between DNA dynamics and the ability of repair proteins to recognize ultraviolet (UV) radiation damage sites.
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Details
- Title
- Pre-melting dynamics of DNA and its relation to specific functions
- Creators
- Boian Alexandrov - Theoretical Division, Los Alamos National Laboratory, Los Alamos, NM 87545, USANikolaos K VoulgarakisKim O RasmussenAnny UshevaAlan R Bishop
- Publication Details
- Journal of physics. Condensed matter, Vol.21(3), pp.034107-034107 (8)
- Academic Unit
- Mathematics and Statistics, Department of
- Publisher
- England
- Grant note
- R01 GM073911 / NIGMS NIH HHS R01 HL062458 / NHLBI NIH HHS
- Identifiers
- 99900546890201842
- Language
- English
- Resource Type
- Journal article