Preference for Gamma-Hydroxybutyrate (GHB) in Current Users

John M Roll; Thomas Newton; Joy Chudzynski; Jennifer M Cameron; Sterling McPherson; Timothy Fong; Matt Torrington

doi:10.1901/jeab.2012.97-323

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Preference for Gamma-Hydroxybutyrate (GHB) in Current Users

Journal article

Open access

Peer reviewed

Preference for Gamma-Hydroxybutyrate (GHB) in Current Users

John M Roll, Thomas Newton, Joy Chudzynski, Jennifer M Cameron, Sterling McPherson, Timothy Fong and Matt Torrington

Journal of the experimental analysis of behavior, Vol.97(3), pp.323-331

05/2012

DOI: https://doi.org/10.1901/jeab.2012.97-323

Handle:

https://hdl.handle.net/2376/118257

PMCID: PMC3372955

PMID: 22693361

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https://doi.org/10.1901/jeab.2012.97-323View

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Abstract

Multiple Choice Procedure (MCP)

Gamma-Hydroxybutyrate (GHB)

reinforcer efficacy

substance abuse

Gamma-hydroxybutyrate (GHB) is a drug with significant abuse potential. The present study aimed to assess the relative value of escalating doses of GHB to current GHB users via the Multiple Choice Procedure (MCP), and to validate that the dose rated highest with the MCP would be self-administered at a greater rate than placebo. Participants were 5 current GHB users who were not currently trying to stop using GHB. To examine the value of escalating doses of GHB, the following doses of GHB were used: 0 (placebo), 12.5, 25, 37.5, and 50 mg/kg. Participants typically assigned higher doses of GHB had higher crossover points on the MCP. During choice sessions, participants made repeated choices between administering GHB, placebo or nothing. All participants selected GHB exclusively (5 out of 5 instances) except for one participant who selected GHB on 4 out of 5 instances, thus 96% (i.e., 24/25) of choices were for active GHB. Based on these data, GHB appears likely to function as a dose-dependent reinforcer for humans based on our sample.

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Details

Title: Preference for Gamma-Hydroxybutyrate (GHB) in Current Users
Creators: John M Roll - Washington State University, Program of Excellence in the Addictions
Thomas Newton - menninger department of psychiatry, baylor college of medicine
Joy Chudzynski - UCLA Integrated Substance Abuse Programs, Behavioral Pharmacology Unit
Jennifer M Cameron - Washington State University, Program of Excellence in the Addictions
Sterling McPherson - Washington State University, Program of Excellence in the Addictions
Timothy Fong - UCLA Integrated Substance Abuse Programs, Behavioral Pharmacology Unit
Matt Torrington - UCLA Integrated Substance Abuse Programs, Behavioral Pharmacology Unit
Publication Details: Journal of the experimental analysis of behavior, Vol.97(3), pp.323-331
Academic Unit: Elson S. Floyd College of Medicine; Medical Education and Clinical Science, Department of
Publisher: Society for the Experimental Analysis of Behavior, Inc; Bloomington, Indiana
Identifiers: 99900548040401842
Language: English
Resource Type: Journal article