Journal article
Pregabalin enhances nonrapid eye movement sleep
The Journal of pharmacology and experimental therapeutics, Vol.299(3), pp.1095-1105
12/2001
Handle:
https://hdl.handle.net/2376/106474
PMID: 11714899
Abstract
Pregabalin, an analog of gamma-aminobutyric acid (GABA) that does not interact with GABA receptors, is in development as an analgesic, an anticonvulsant, and an anxiolytic. We evaluated the potential somnogenic actions of pregabalin in rats and compared it to those of triazolam, a widely used hypnotic. Pregabalin increased the duration of nonrapid eye movement sleep (NREMS) and decreased rapid eye movement sleep (REMS) after either dark onset or light onset administration. Triazolam increased duration of NREMS and had no effect on duration of REMS. Pregabalin markedly increased the duration of NREMS episodes and decreased the number of NREMS episodes. Power spectrum analysis revealed pregabalin-induced dose-dependent increases in relative delta power after administration. In contrast, triazolam decreased electroencephalographic power density in low frequency bands. Results suggest that pregabalin is a potential sleep modulating agent.
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Details
- Title
- Pregabalin enhances nonrapid eye movement sleep
- Creators
- T Kubota - Department of Veterinary and Comparative Anatomy, Pharmacology, and Physiology, Washington State University, College of Veterinary Medicine, Pullman, Washington 99164-6520, USAJ FangL T MeltzerJ M Krueger
- Publication Details
- The Journal of pharmacology and experimental therapeutics, Vol.299(3), pp.1095-1105
- Academic Unit
- Integrative Physiology and Neuroscience, Department of
- Publisher
- United States
- Identifiers
- 99900546814101842
- Language
- English
- Resource Type
- Journal article