Journal article
Prenatal lesions in an ovine fetus with GM1 gangliosidosis
American journal of medical genetics, Vol.39(1), pp.106-111
04/01/1991
Handle:
https://hdl.handle.net/2376/110380
PMID: 1907804
Abstract
Sheep affected with ovine GM1 gangliosidosis are normal at birth and develop clinical signs, initially ataxia, commencing at approximately 5 months of age, which progresses rapidly to recumbency. Superovulation and embryo transfer techniques were applied to a flock of carrier sheep of ovine GM1 gangliosidosis to increase the numbers of carrier and affected animals. A recipient ewe with 3 at‐risk fetuses died at 4 months of gestation (normal ovine gestation is 5 months), and spectrofluorimetric assay of cerebral lysosomal β‐galactosidase of the fetuses showed that 2 were carriers and one was an affected fetus. The affected fetus had marked cytoplasmic enlargement and vacuolization of central and peripheral nervous system neuronal soma and of hepatocytes and renal epithelial cells. Lectin histochemistry indicated abnormal storage of complex carbohydrates, with terminal saccharide moieties consisting of β‐galactose, N‐acetylneuraminic acid, and N‐acetylgalactosamine. This case underlines the need for prenatal initiation of therapy and also demonstrates that vacuolization alone is not the cause of clinical signs in this lysosomal storage disease in that clinical signs do not commence until at least 5 months after vacuolization is histologically apparent.
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Details
- Title
- Prenatal lesions in an ovine fetus with GM1 gangliosidosis
- Creators
- Robert D MurnaneRaymond W WrightAmelia J Ahern‐RindellDavid J Prieur
- Publication Details
- American journal of medical genetics, Vol.39(1), pp.106-111
- Academic Unit
- Animal Sciences, Department of
- Publisher
- Wiley Subscription Services, Inc., A Wiley Company; New York
- Number of pages
- 6
- Identifiers
- 99900547147401842
- Language
- English
- Resource Type
- Journal article