Journal article
Prenatal nicotine alters vigilance states and AchR gene expression in the neonatal rat: implications for SIDS
American journal of physiology. Regulatory, integrative and comparative physiology, Vol.280(4), pp.R1134-R1140
04/01/2001
Handle:
https://hdl.handle.net/2376/100348
PMID: 11247836
Abstract
Maternal smoking is a major risk factor for sudden infant death syndrome (SIDS). The mechanisms by which cigarette smoke predisposes infants to SIDS are not known. We examined the effects of prenatal nicotine exposure on sleep/wake ontogenesis and central cholinergic receptor gene expression in the neonatal rat. Prenatal nicotine exposure transiently increased sleep continuity and accelerated sleep/wake ontogeny in the neonatal rat. Prenatal nicotine also upregulated nicotinic and muscarinic cholinergic receptor mRNAs in brain regions involved in regulating vigilance states. These findings suggest that the nicotine contained in cigarette smoke may predispose human infants to SIDS by interfering with the normal maturation of sleep and wake.
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Details
- Title
- Prenatal nicotine alters vigilance states and AchR gene expression in the neonatal rat: implications for SIDS
- Creators
- Marcos G Frank - Department of Physiology, University of California at San Francisco, San Francisco, California 94143Hilary Srere - Department of Biological Sciences, Stanford University, Stanford 94305; andCarlos Ledezma - Department of Biological Sciences, Stanford University, Stanford 94305; andBruce O'Hara - Department of Biological Sciences, Stanford University, Stanford 94305; andH. Craig Heller - Department of Biological Sciences, Stanford University, Stanford 94305; and
- Publication Details
- American journal of physiology. Regulatory, integrative and comparative physiology, Vol.280(4), pp.R1134-R1140
- Academic Unit
- Biomedical Sciences, Department of
- Identifiers
- 99900546794401842
- Language
- English
- Resource Type
- Journal article