Journal article
Preparation and cell–materials interactions of plasma sprayed strontium-containing hydroxyapatite coating
Surface & coatings technology, Vol.201(8), pp.4685-4693
2007
Handle:
https://hdl.handle.net/2376/112014
Abstract
The use of strontium-containing hydroxyapatite (Sr-HA) as a biomaterial has been reported recently.
In vitro and
in vivo studies have shown that Sr-HA promotes osteoblast response and stimulates new bone formation. In order to extend its usage to major load-bearing applications, such as artificial hip replacement, it has been proposed that the material could be used in the form of a coating on implant surfaces. This paper reports a preliminary study of biocompatibility of plasma sprayed Sr-HA coatings on a metallic substrate. Coatings of Sr-HA containing 10 mol% Sr
2+ was produced on titanium alloy substrates. The coating exhibited good bonding with the substrate. The bioactivity of Sr-HA coating was evaluated
in vitro by immersion in simulated body fluid (SBF). After immersion in SBF, Sr-HA coating exhibited great ability to induce apatite precipitation on its surface. The possible effects of cell–materials interactions of Sr-HA coating were examined by culturing osteoprecursor cells (OPC1) on coating surfaces. The effect of Sr-HA was also compared to a hydroxyapatite (HA) coating, which is widely used in orthopedics and dentistry. The results indicated that Sr-HA coating had good biocompatibility with human osteoblasts. OPC1 cells survived and proliferated well on the surface of coating. Sr-HA coating promoted OPC1 cells attachment, and more local contacts were produced on the surface. The presence of Sr stimulated OPC1 cell differentiation and ALP expression. No deleterious effect on ECM formation and mineralization was found with Sr-HA coating. The results indicated that Sr-HA coating had good mechanical properties and bioactivity
in vitro.
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Details
- Title
- Preparation and cell–materials interactions of plasma sprayed strontium-containing hydroxyapatite coating
- Creators
- Weichang Xue - W. M. Keck Biomedical Materials Research Laboratory, Washington State University, Pullman, Washington 99164, United StatesHoward L Hosick - W. M. Keck Biomedical Materials Research Laboratory, Washington State University, Pullman, Washington 99164, United StatesAmit Bandyopadhyay - W. M. Keck Biomedical Materials Research Laboratory, Washington State University, Pullman, Washington 99164, United StatesSusmita Bose - W. M. Keck Biomedical Materials Research Laboratory, Washington State University, Pullman, Washington 99164, United StatesChuanxian Ding - Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, ChinaK.D.K Luk - Department of Orthopaedic and Traumatology, The University of Hong Kong, Hong Kong, ChinaK.M.C Cheung - Department of Orthopaedic and Traumatology, The University of Hong Kong, Hong Kong, ChinaW.W Lu - Department of Orthopaedic and Traumatology, The University of Hong Kong, Hong Kong, China
- Publication Details
- Surface & coatings technology, Vol.201(8), pp.4685-4693
- Academic Unit
- Mechanical and Materials Engineering, School of
- Publisher
- Elsevier B.V
- Identifiers
- 99900547901801842
- Language
- English
- Resource Type
- Journal article