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CC BY V4.0, Open Access
Journal article
Preterm birth buccal cell epigenetic biomarkers to facilitate preventative medicine
Scientific reports, Vol.12(1), pp.3361-3361
03/01/2022
PMCID: PMC8888575
PMID: 35232984
Abstract
Preterm birth is the major cause of newborn and infant mortality affecting nearly one in every ten live births. The current study was designed to develop an epigenetic biomarker for susceptibility of preterm birth using buccal cells from the mother, father, and child (triads). An epigenome-wide association study (EWAS) was used to identify differential DNA methylation regions (DMRs) using a comparison of control term birth versus preterm birth triads. Epigenetic DMR associations with preterm birth were identified for both the mother and father that were distinct and suggest potential epigenetic contributions from both parents. The mother (165 DMRs) and female child (136 DMRs) at p < 1e-04 had the highest number of DMRs and were highly similar suggesting potential epigenetic inheritance of the epimutations. The male child had negligible DMR associations. The DMR associated genes for each group involve previously identified preterm birth associated genes. Observations identify a potential paternal germline contribution for preterm birth and identify the potential epigenetic inheritance of preterm birth susceptibility for the female child later in life. Although expanded clinical trials and preconception trials are required to optimize the potential epigenetic biomarkers, such epigenetic biomarkers may allow preventative medicine strategies to reduce the incidence of preterm birth.
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Details
- Title
- Preterm birth buccal cell epigenetic biomarkers to facilitate preventative medicine
- Creators
- Paul Winchester - Franciscan University of SteubenvilleEric Nilsson - Washington State UniversityDaniel Beck - Washington State UniversityMichael K Skinner - Washington State University
- Publication Details
- Scientific reports, Vol.12(1), pp.3361-3361
- Academic Unit
- Biological Sciences, School of
- Identifiers
- 99901080823601842
- Language
- English
- Resource Type
- Journal article