Journal article
Previous lung diseases and lung cancer risk: a pooled analysis from the International Lung Cancer Consortium
American journal of epidemiology, Vol.176(7), pp.573-585
10/01/2012
Handle:
https://hdl.handle.net/2376/105788
PMCID: PMC3530374
PMID: 22986146
Abstract
To clarify the role of previous lung diseases (chronic bronchitis, emphysema, pneumonia, and tuberculosis) in the development of lung cancer, the authors conducted a pooled analysis of studies in the International Lung Cancer Consortium. Seventeen studies including 24,607 cases and 81,829 controls (noncases), mainly conducted in Europe and North America, were included (1984-2011). Using self-reported data on previous diagnoses of lung diseases, the authors derived study-specific effect estimates by means of logistic regression models or Cox proportional hazards models adjusted for age, sex, and cumulative tobacco smoking. Estimates were pooled using random-effects models. Analyses stratified by smoking status and histology were also conducted. A history of emphysema conferred a 2.44-fold increased risk of lung cancer (95% confidence interval (CI): 1.64, 3.62 (16 studies)). A history of chronic bronchitis conferred a relative risk of 1.47 (95% CI: 1.29, 1.68 (13 studies)). Tuberculosis (relative risk = 1.48, 95% CI: 1.17, 1.87 (16 studies)) and pneumonia (relative risk = 1.57, 95% CI: 1.22, 2.01 (12 studies)) were also associated with lung cancer risk. Among never smokers, elevated risks were observed for emphysema, pneumonia, and tuberculosis. These results suggest that previous lung diseases influence lung cancer risk independently of tobacco use and that these diseases are important for assessing individual risk.
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- Title
- Previous lung diseases and lung cancer risk: a pooled analysis from the International Lung Cancer Consortium
- Creators
- Darren R Brenner - Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, CanadaPaolo BoffettaEric J DuellHeike BickeböllerAlbert RosenbergerValerie McCormackJoshua E MuscatPing YangH-Erich WichmannIrene Brueske-HohlfeldAnn G SchwartzMichele L CoteAnne TjønnelandSøren FriisLoic Le MarchandZuo-Feng ZhangHal MorgensternNeonila Szeszenia-DabrowskaJolanta LissowskaDavid ZaridzePeter RudnaiEleonora FabianovaLenka ForetovaVladimir JanoutVladimir BenckoMiriam SchejbalovaPaul BrennanIoan N MatesPhilip LazarusJohn K FieldOlaide RajiJohn R McLaughlinGeoffrey LiuJohn WienckeMonica NeriDonatella UgoliniAngeline S AndrewQing LanWei HuIrene OrlowBernard J ParkRayjean J Hung
- Publication Details
- American journal of epidemiology, Vol.176(7), pp.573-585
- Academic Unit
- Pharmaceutical Sciences, Department of
- Publisher
- United States
- Grant note
- R01CA060691 / NCI NIH HHS CA-113710 / NCI NIH HHS ES06717 / NIEHS NIH HHS R01 CA060691 / NCI NIH HHS P30 CA023108 / NCI NIH HHS R01CA87895 / NCI NIH HHS R01 CA140314 / NCI NIH HHS N01-PC35145 / NCI NIH HHS Canadian Institutes of Health Research P30CA22453 / NCI NIH HHS N01PC35145 / NCI NIH HHS R01 ES006717 / NIEHS NIH HHS P30 CA022453 / NCI NIH HHS T32 CA113710 / NCI NIH HHS P20 RR018787 / NCRR NIH HHS R01 CA087895 / NCI NIH HHS R25 CA113710 / NCI NIH HHS P20RR018787 / NCRR NIH HHS
- Identifiers
- 99900546691501842
- Language
- English
- Resource Type
- Journal article