Journal article
Processing and biocompatibility evaluation of laser processed porous titanium
Acta biomaterialia, Vol.3(6), pp.1007-1018
2007
Handle:
https://hdl.handle.net/2376/108519
PMID: 17627910
Abstract
The Laser Engineered Net Shaping (LENS™) method was used to fabricate porous Ti implants. Porous Ti structures with controlled porosity in the range of 17–58
vol.% and pore size up to 800
μm were produced by controlling LENS™ parameters, which showed a broad range of mechanical strength of 24–463
MPa and a low Young’s modulus of 2.6–44
GPa. The effects of porous structure on bone cell responses were evaluated
in vitro with human osteoblast cells (OPC1). The results showed that cells spread well on the surface of porous Ti and formed strong local adhesion. MTT assay indicated LENS™ processed porous Ti provides a preferential surface for bone cell proliferation. Porous Ti samples also stimulated faster OPC1 cell differentiation compared with polished Ti sheet, which could be due to the change in cell morphology within the pores of Ti samples. More extracellular matrix and a higher level of alkaline phosphatase expression were found on the porous samples than on the Ti sheet. This can be beneficial for faster integration of porous implant with host bone tissue. The results obtained also indicated that a critical pore size of 200
μm or higher is needed for cell ingrowth into the pores, below which OPC1 cells bridged the pore surface without any growth in the pores.
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Details
- Title
- Processing and biocompatibility evaluation of laser processed porous titanium
- Creators
- Weichang XueB. Vamsi KrishnaAmit BandyopadhyaySusmita Bose
- Publication Details
- Acta biomaterialia, Vol.3(6), pp.1007-1018
- Academic Unit
- Mechanical and Materials Engineering, School of
- Publisher
- Elsevier Ltd
- Identifiers
- 99900547270801842
- Language
- English
- Resource Type
- Journal article