Journal article
Processing and characterization of porous alumina scaffolds
Journal of materials science. Materials in medicine, Vol.13(1), pp.23-28
01/2002
Handle:
https://hdl.handle.net/2376/116735
PMID: 15348200
Abstract
Bioceramic materials are used for the reconstruction or replacement of the damaged parts of the human body. In this study an improved procedure is described for producing ceramic scaffolds with controlled porosity. Bioinert alumina ceramic was used to make porous scaffolds by using indirect fused deposition modeling (FDM), a commercially available rapid prototyping (RP) technique. Porous alumina samples were coated with hydroxyapatite (HAp) to increase the biocompatibility of the scaffolds. Initial biological responses of the porous alumina scaffolds were assessed in vitro using rat pituitary tumor cells (PR1). Both porous alumina and HAp coated alumina ceramics provided favorable sites for cell attachments in a physiological solution at 37 °C, which suggests that these materials would promote good bonding while used as bone implants in vivo. Based on these preliminary studies, similar tests were performed with human osteosarcoma cells. Cell proliferation studies show that both the ceramic materials can potentially provide a non-toxic surface for bone bonding when implanted in vivo.
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Details
- Title
- Processing and characterization of porous alumina scaffolds
- Creators
- Susmita Bose - School of Mechanical and Materials Engineering USAJens Darsell - School of Mechanical and Materials Engineering USAHoward Hosick - School of Biological Sciences and Molecular Biosciences USALihua Yang - College of Veterinary Medicine Washington State University Pullman WA 99164-2920 USADipak Sarkar - College of Veterinary Medicine Washington State University Pullman WA 99164-2920 USAAmit Bandyopadhyay - School of Mechanical and Materials Engineering USA
- Publication Details
- Journal of materials science. Materials in medicine, Vol.13(1), pp.23-28
- Academic Unit
- Mechanical and Materials Engineering, School of
- Publisher
- Kluwer Academic Publishers; Boston
- Identifiers
- 99900547464301842
- Language
- English
- Resource Type
- Journal article