Journal article
Prospective study of effect modification by Toll-like receptor 4 variation on the association between Trichomonas vaginalis serostatus and prostate cancer
Cancer causes & control, Vol.24(1), pp.175-180
01/2013
Handle:
https://hdl.handle.net/2376/107747
PMCID: PMC3549464
PMID: 23179660
Abstract
In previous studies, we observed a positive association between Trichomonas vaginalis serostatus and risk of prostate cancer, particularly aggressive cancer, which we hypothesized might be due to T. vaginalis-mediated intraprostatic inflammation and cell damage. To explore this hypothesis further, we investigated effect modification by Toll-like receptor 4 (TLR4) variation on this association. We hypothesized that TLR4 variation might serve a marker of the anti-trichomonad immune response because T. vaginalis has been shown to elicit inflammation through this receptor.We previously genotyped the non-synonymous TLR4 single nucleotide polymorphism (SNP), rs4986790, and determined T. vaginalis serostatus for 690 incident prostate cancer cases and 692 controls in a nested case–control study within the Health Professionals Follow-up Study.A non-significant suggestion of effect modification was observed by rs4986790 carrier status on the association between T. vaginalis serostatus and prostate cancer risk (p interaction = 0.07). While no association was observed among men homozygous wildtype for this SNP (odds ratio (OR) = 1.23, 95 % confidence interval (CI): 0.86–1.77), a positive association was observed among variant carriers (OR = 4.16, 95 % CI: 1.32–13.1).Although not statistically significant, TLR4 variation appeared to influence the association between T. vaginalis serostatus and prostate cancer risk consistent with the hypothesis that inflammation plays a role in this association. Larger studies will be necessary to explore this possible effect modification further.
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Details
- Title
- Prospective study of effect modification by Toll-like receptor 4 variation on the association between Trichomonas vaginalis serostatus and prostate cancer
- Creators
- Yen Chen - Department of Public Health, College of Public Health National Taiwan University Taipei TaiwanYi Huang - Institute of Epidemiology and Preventive Medicine, College of Public Health National Taiwan University Taipei TaiwanElizabeth Platz - Department of Epidemiology Johns Hopkins Bloomberg School of Public Health Baltimore MD USAJohn Alderete - School of Molecular Biosciences Washington State University Pullman WA USALu Zheng - Department of Biostatistics Harvard School of Public Health Boston MA USAJennifer Rider - Department of Epidemiology Harvard School of Public Health Boston MA USAPeter Kraft - Department of Epidemiology Harvard School of Public Health Boston MA USAEdward Giovannucci - Department of Nutrition Harvard School of Public Health Boston MA USASiobhan Sutcliffe - Division of Public Health Sciences, Department of Surgery, Alvin J. Siteman Cancer Center Washington University School of Medicine St. Louis MO USA
- Publication Details
- Cancer causes & control, Vol.24(1), pp.175-180
- Academic Unit
- Molecular Biosciences, School of
- Publisher
- Springer Netherlands; Dordrecht
- Identifiers
- 99900547237901842
- Language
- English
- Resource Type
- Journal article