Journal article
Prostate-specific membrane antigen-targeted photodynamic therapy induces rapid cytoskeletal disruption
Cancer letters, Vol.296(1), pp.106-112
2010
Handle:
https://hdl.handle.net/2376/107168
PMCID: PMC3201799
PMID: 20452720
Abstract
Prostate-specific membrane antigen (PSMA), an established enzyme–biomarker for prostate cancer, has attracted considerable attention as a target for imaging and therapeutic applications. We aimed to determine the effects of PSMA-targeted photodynamic therapy (PDT) on cytoskeletal networks in prostate cancer cells. PSMA-targeted PDT resulted in rapid disruption of microtubules (α-/β-tubulin), microfilaments (actin), and intermediate filaments (cytokeratin 8/18) in the cytoplasm of LNCaP cells. The collapse of cytoplasmic microtubules and the later nuclear translocation of α-/β-tubulin were the most dramatic alternation. It is likely that these early changes of cytoskeletal networks are partly involved in the initiation of cell death.
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Details
- Title
- Prostate-specific membrane antigen-targeted photodynamic therapy induces rapid cytoskeletal disruption
- Creators
- Tiancheng Liu - Department of Chemistry, Washington State University, Pullman, WA 99164, USALisa Y Wu - Department of Chemistry, Washington State University, Pullman, WA 99164, USAClifford E Berkman - Department of Chemistry, Washington State University, Pullman, WA 99164, USA
- Publication Details
- Cancer letters, Vol.296(1), pp.106-112
- Academic Unit
- Chemistry, Department of
- Publisher
- Elsevier Ireland Ltd
- Identifiers
- 99900546885501842
- Language
- English
- Resource Type
- Journal article