Journal article
Protection by U-50,488H against β-chlornaltrexamine antagonism of nitrous oxide antinociception in mice
Brain research, Vol.549(1), pp.162-164
1991
Handle:
https://hdl.handle.net/2376/113573
PMID: 1832578
Abstract
Nitrous oxide antinociception in the abdominal constriction test was significantly reduced in mice pretreated intracerebroventricularly (i.c.v.) with β-chlornaltrexamine (β-CNA). However, this antagonism was reversed when the β-CNA was co-administered i.c.v. with the κ-opioid ligand U-50,488H but not the μ-opioid ligand CTOP. These findings further demonstrate that nitrous oxide antinociception in the mouse abdominal constriction paradigm is mediated by κ- but not μ-opioid receptors.
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Details
- Title
- Protection by U-50,488H against β-chlornaltrexamine antagonism of nitrous oxide antinociception in mice
- Creators
- Raymond M QuockJanet Mueller
- Publication Details
- Brain research, Vol.549(1), pp.162-164
- Academic Unit
- Psychology, Department of
- Publisher
- Elsevier B.V
- Identifiers
- 99900547448801842
- Language
- English
- Resource Type
- Journal article