Journal article
Protective Effects of Broadly Neutralizing Immunoglobulin against Homologous and Heterologous Equine Infectious Anemia Virus Infection in Horses with Severe Combined Immunodeficiency
Journal of virology, Vol.85(13), pp.6814-6818
Notes
07/2011
Handle:
https://hdl.handle.net/2376/113484
PMCID: PMC3126505
PMID: 21543497
Abstract
Using the equine infectious anemia virus (EIAV) lentivirus model system, we previously demonstrated protective effects of broadly neutralizing immune plasma in young horses (foals) with severe combined immunodeficiency (SCID). However,
in vivo
selection of a neutralization-resistant envelope variant occurred. Here, we determined the protective effects of purified immunoglobulin with more potent broadly neutralizing activity. Overall, protection correlated with the breadth and potency of neutralizing activity
in vitro
. Four of five SCID foals were completely protected against homologous challenge, while partial protection occurred following heterologous challenge. These results support the inclusion of broadly neutralizing antibodies in lentivirus control strategies.
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Details
- Title
- Protective Effects of Broadly Neutralizing Immunoglobulin against Homologous and Heterologous Equine Infectious Anemia Virus Infection in Horses with Severe Combined Immunodeficiency
- Creators
- Sandra D Taylor - Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington 99164-7040Steven R Leib - Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington 99164-7040Wuwei Wu - Department of Animal Science, Iowa State University, Ames, Iowa 50011Robert Nelson - Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington 99164-7040Susan Carpenter - Department of Animal Science, Iowa State University, Ames, Iowa 50011Robert H Mealey - Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington 99164-7040
- Publication Details
- Journal of virology, Vol.85(13), pp.6814-6818
- Academic Unit
- Veterinary Clinical Sciences, Department of
- Series
- Notes
- Publisher
- American Society for Microbiology; 1752 N St., N.W., Washington, DC
- Identifiers
- 99900547441001842
- Language
- English
- Resource Type
- Journal article