Journal article
Psychobiological allostasis: resistance, resilience and vulnerability
Trends in cognitive sciences, Vol.15(12), pp.576-584
12/2011
Handle:
https://hdl.handle.net/2376/109297
PMID: 22078931
Abstract
The brain and body need to adapt constantly to changing social and physical environments. A key mechanism for this adaptation is the 'stress response', which is necessary and not negative in and of itself. The term 'stress', however, is ambiguous and has acquired negative connotations. We argue that the concept of allostasis can be used instead to describe the mechanisms employed to achieve stability of homeostatic systems through active intervention (adaptive plasticity). In the context of allostasis, resilience denotes the ability of an organism to respond to stressors in the environment by means of the appropriate engagement and efficient termination of allostatic responses. In this review, we discuss the neurobiological and organismal factors that modulate resilience, such as growth factors, chaperone molecules and circadian rhythms, and highlight its consequences for cognition and behavior.
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Details
- Title
- Psychobiological allostasis: resistance, resilience and vulnerability
- Creators
- Ilia N Karatsoreos - Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, 1230 York Avenue, New York, New York 10065, USABruce S McEwen
- Publication Details
- Trends in cognitive sciences, Vol.15(12), pp.576-584
- Academic Unit
- Integrative Physiology and Neuroscience, Department of
- Publisher
- England
- Identifiers
- 99900546921101842
- Language
- English
- Resource Type
- Journal article