Journal article
Quantitative trait loci for hip dysplasia in a crossbreed canine pedigree
Mammalian genome, Vol.16(9), pp.720-730
09/2005
Handle:
https://hdl.handle.net/2376/103936
PMID: 16245029
Abstract
Canine hip dysplasia is a common developmental inherited trait characterized by hip laxity, subluxation or incongruity of the femoral head and acetabulum in affected hips. The inheritance pattern is complex and the mutations contributing to trait expression are unknown. In the study reported here, 240 microsatellite markers distributed in 38 autosomes and the X chromosome were genotyped on 152 dogs from three generations of a crossbred pedigree based on trait-free Greyhound and dysplastic Labrador Retriever founders. Interval mapping was undertaken to map the QTL underlying the quantitative dysplastic traits of maximum passive hip laxity (the distraction index), the dorsolateral subluxation score, and the Norberg angle. Permutation testing was used to derive the chromosome-wide level of significance at p < 0.05 for each QTL. Chromosomes 4, 9, 10, 11 (p < 0.01), 16, 20, 22, 25, 29 (p < 0.01), 30, 35, and 37 harbor putative QTL for one or more traits. Successful detection of QTL was due to the crossbreed pedigree, multiple-trait measurements, control of environmental background, and marked advancement in canine mapping tools.
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Details
- Title
- Quantitative trait loci for hip dysplasia in a crossbreed canine pedigree
- Creators
- Rory Todhunter - Department of Clinical Sciences, Box 32 College of Veterinary Medicine Cornell University Ithaca New York 14853 USARaluca Mateescu - Department of Clinical Sciences, Box 32 College of Veterinary Medicine Cornell University Ithaca New York 14853 USAGeorge Lust - James A. Baker Institute for Animal Health, College of Veterinary Medicine Cornell University Ithaca New York 14853 USANancy Burton-Wurster - James A. Baker Institute for Animal Health, College of Veterinary Medicine Cornell University Ithaca New York 14853 USANathan Dykes - Department of Clinical Sciences, Box 32 College of Veterinary Medicine Cornell University Ithaca New York 14853 USAStuart Bliss - Department of Clinical Sciences, Box 32 College of Veterinary Medicine Cornell University Ithaca New York 14853 USAAlma Williams - James A. Baker Institute for Animal Health, College of Veterinary Medicine Cornell University Ithaca New York 14853 USAMargaret Vernier-Singer - Department of Clinical Sciences, Box 32 College of Veterinary Medicine Cornell University Ithaca New York 14853 USAElizabeth Corey - James A. Baker Institute for Animal Health, College of Veterinary Medicine Cornell University Ithaca New York 14853 USACarlos Harjes - Department of Clinical Sciences, Box 32 College of Veterinary Medicine Cornell University Ithaca New York 14853 USARichard Quaas - Department of Animal Breeding, College of Agriculture and Life Sciences Cornell University Ithaca New York 14853 USAZhiwu Zhang - Department of Animal Breeding, College of Agriculture and Life Sciences Cornell University Ithaca New York 14853 USARobert Gilbert - Department of Clinical Sciences, Box 32 College of Veterinary Medicine Cornell University Ithaca New York 14853 USADietrich Volkman - Department of Clinical Sciences, Box 32 College of Veterinary Medicine Cornell University Ithaca New York 14853 USAGeorge Casella - Department of Statistics University of Florida Gainesville Florida 32611 USARongling Wu - Department of Statistics University of Florida Gainesville Florida 32611 USAGregory Acland - James A. Baker Institute for Animal Health, College of Veterinary Medicine Cornell University Ithaca New York 14853 USA
- Publication Details
- Mammalian genome, Vol.16(9), pp.720-730
- Academic Unit
- Crop and Soil Sciences, Department of
- Publisher
- Springer-Verlag; New York
- Identifiers
- 99900547088901842
- Language
- English
- Resource Type
- Journal article