Journal article
Quinoa intake reduces plasma and liver cholesterol, lessens obesity-associated inflammation, and helps to prevent hepatic steatosis in obese db/db mouse
Food chemistry, Vol.287, pp.107-114
07/30/2019
Handle:
https://hdl.handle.net/2376/106542
PMID: 30857678
Abstract
The purpose of this study was to investigate if quinoa (Chenopodium quinoa Willd.), a good source of nutrients, fibre, and phytochemicals, can modulate risk disease biomarkers on obese-diabetic (db/db) mice. The db/db mice fed quinoa-supplemented (quinoa) or AIN-93G diet (obese) were compared to lean control fed AIN-93G diet. Quinoa intake reduced at significant level plasma total-cholesterol (total-c), LDL-c, and oxidized-LDL to levels similar to lean; lessened protein carbonyls and interleukin (IL)-6. The hepatic steatosis and total-c accumulation in liver were also similar between lean and quinoa and lower than obese. Quinoa fibre and phytochemicals may have contributed to these health benefits. However, quinoa intake increased plasma insulin and did not protect from other pathophysiological manifestations of the db/db research model. More studies are needed with other research models and quinoa doses achievable by human diet to validate the clinical relevance of this study.
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Details
- Title
- Quinoa intake reduces plasma and liver cholesterol, lessens obesity-associated inflammation, and helps to prevent hepatic steatosis in obese db/db mouse
- Creators
- Giuliana D Noratto - Department of Nutrition and Food Science, Texas A&M University, College Station, TX, United States; School of Food Science, Washington State University, Pullman, WA, United States. Electronic address: gnoratto@tamu.eduKevin Murphy - Department of Crop and Soil Sciences, Washington State University, Pullman, WA, United StatesBoon P Chew - Department of Nutrition and Food Science, Texas A&M University, College Station, TX, United States
- Publication Details
- Food chemistry, Vol.287, pp.107-114
- Academic Unit
- Crop and Soil Sciences, Department of; Food Science, School of
- Publisher
- England
- Identifiers
- 99900547063901842
- Language
- English
- Resource Type
- Journal article