Journal article
Randomized, placebo-controlled trial of sertraline and contingency management for the treatment of methamphetamine dependence
Drug and alcohol dependence, Vol.85(1), pp.12-18
2006
Handle:
https://hdl.handle.net/2376/103116
PMID: 16621339
Abstract
Methamphetamine dependence and associated medical and psychiatric concerns are significant public health issues. This project evaluated the efficacy of sertraline (50
mg bid) and contingency management (CM) for the treatment of methamphetamine dependence.
In this randomized, placebo-controlled, double-blind trial, participants completed a 2-week non-medication baseline and were randomized to one of four conditions for 12 weeks: sertraline plus CM (
n
=
61), sertraline-only (
n
=
59), matching placebo plus CM (
n
=
54), or matching placebo-only (
n
=
55). All participants attended clinic thrice-weekly for data collection, medication dispensing, and relapse prevention groups. Outcomes included methamphetamine use (urine drug screening and self-reported days of use), retention (length of stay), drug craving (visual analogue scale), and mood symptoms (Beck Depression Inventory).
No statistically significant main or interaction effects for sertraline or CM in reducing methamphetamine use were observed using a generalized estimating equation (GEE), although post hoc analyses showed the sertraline-only condition had significantly poorer retention than other conditions (
χ
2 (3)
=
8.40,
p
<
0.05). Sertraline conditions produced significantly more adverse events than placebo conditions. A significantly higher proportion of participants in CM conditions achieved three consecutive weeks of methamphetamine abstinence than those in non-CM conditions.
These data do not demonstrate improved outcomes for sertraline versus placebo for treatment of methamphetamine dependence; indeed, they suggest sertraline is contraindicated for methamphetamine dependence. Findings provide support for the use of contingency management for treatment of methamphetamine dependence.
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Details
- Title
- Randomized, placebo-controlled trial of sertraline and contingency management for the treatment of methamphetamine dependence
- Creators
- Steven Shoptaw - Center for Health Promotion and Disease Prevention, Department of Family Medicine, David Geffen School of Medicine at UCLA, 10880 Wilshire Blvd, Suite 1800, Los Angeles, CA 90024, United StatesAlice Huber - Integrated Substance Abuse Programs, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at UCLA, 11075 Santa Monica Blvd, Suite 200, Los Angeles, CA 90025, United StatesJames Peck - Integrated Substance Abuse Programs, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at UCLA, 11075 Santa Monica Blvd, Suite 200, Los Angeles, CA 90025, United StatesXiaowei Yang - Department of Public Health Sciences One Shields Avenue, TB-168, University of California, Davis, CA 95616-8638, United StatesJuanmei Liu - Department of Psychology-Measurement, UCLA, Box 951563, 1285 FH, Los Angeles, CA 90095-1563, United StatesJeff Jeff Dang - Center for Health Promotion and Disease Prevention, Department of Family Medicine, David Geffen School of Medicine at UCLA, 10880 Wilshire Blvd, Suite 1800, Los Angeles, CA 90024, United StatesJohn Roll - WSU-Spokane Health Sciences, Washington State University, P.O. Box 1495, Spokane, WA 99210-1495, United StatesBenjamin Shapiro - Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, 760 Westwood Plaza, C-8 mailroom, Los Angeles, CA 90024, United StatesErin Rotheram-Fuller - Center for Health Promotion and Disease Prevention, Department of Family Medicine, David Geffen School of Medicine at UCLA, 10880 Wilshire Blvd, Suite 1800, Los Angeles, CA 90024, United StatesWalter Ling - Integrated Substance Abuse Programs, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at UCLA, 11075 Santa Monica Blvd, Suite 200, Los Angeles, CA 90025, United States
- Publication Details
- Drug and alcohol dependence, Vol.85(1), pp.12-18
- Academic Unit
- Elson S. Floyd College of Medicine
- Publisher
- Elsevier Ireland Ltd
- Identifiers
- 99900546696901842
- Language
- English
- Resource Type
- Journal article