Journal article
Rapid eye movement sleep promotes cortical plasticity in the developing brain
Science advances, Vol.1(6), pp.e1500105-e1500105
07/01/2015
Handle:
https://hdl.handle.net/2376/107077
PMCID: PMC4646776
PMID: 26601213
Abstract
Rapid eye movement sleep plays a critical role in shaping developing circuits in the cerebral cortex.
Rapid eye movement sleep is maximal during early life, but its function in the developing brain is unknown. We investigated the role of rapid eye movement sleep in a canonical model of developmental plasticity in vivo (ocular dominance plasticity in the cat) induced by monocular deprivation. Preventing rapid eye movement sleep after monocular deprivation reduced ocular dominance plasticity and inhibited activation of a kinase critical for this plasticity (extracellular signal–regulated kinase). Chronic single-neuron recording in freely behaving cats further revealed that cortical activity during rapid eye movement sleep resembled activity present during monocular deprivation. This corresponded to times of maximal extracellular signal–regulated kinase activation. These findings indicate that rapid eye movement sleep promotes molecular and network adaptations that consolidate waking experience in the developing brain.
Metrics
17 Record Views
Details
- Title
- Rapid eye movement sleep promotes cortical plasticity in the developing brain
- Creators
- Michelle C Dumoulin Bridi - Department of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USASara J Aton - Department of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USAJulie Seibt - Department of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USALeslie Renouard - Department of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USATammi Coleman - Department of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USAMarcos G Frank - Department of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
- Publication Details
- Science advances, Vol.1(6), pp.e1500105-e1500105
- Academic Unit
- Biomedical Sciences, Department of
- Publisher
- American Association for the Advancement of Science
- Grant note
- ID0E1WAG1471; HL114161 / ; ID0EM4AG1472; EY019022 / ;
- Identifiers
- 99900546987101842
- Language
- English
- Resource Type
- Journal article