Journal article
Rational Design and Bioimaging Applications of Highly Selective Fluorescence Probes for Hydrogen Polysulfides
Journal of the American Chemical Society, Vol.136(20), pp.7257-7260
05/21/2014
Handle:
https://hdl.handle.net/2376/116157
PMCID: PMC4046760
PMID: 24809803
Abstract
Reactive
sulfur species have received considerable attention due
to their various biological functions. Among these molecules, hydrogen
polysulfides (H
2
S
n
,
n
> 1) are recently suggested to be the actual signaling
molecules derived from hydrogen sulfide (H
2
S). Hydrogen
polysulfides may also have their own biosynthetic pathways. The research
on H
2
S
n
is rapidly growing.
However, the detection of H
2
S
n
is still challenging. In this work we report a H
2
S
n
-mediated benzodithiolone formation under
mild conditions. Based on this reaction, specific fluorescent probes
for H
2
S
n
are prepared and evaluated.
The probe
DSP-3
shows good selectivity and sensitivity
for H
2
S
n
.
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Details
- Title
- Rational Design and Bioimaging Applications of Highly Selective Fluorescence Probes for Hydrogen Polysulfides
- Creators
- Chunrong Liu - Department of ChemistryWei Chen - Department of ChemistryWen Shi - Key Laboratory of Analytical Chemistry for Living BiosystemsBo Peng - Department of ChemistryYu Zhao - Department of ChemistryHuimin Ma - Key Laboratory of Analytical Chemistry for Living BiosystemsMing Xian - Department of Chemistry
- Publication Details
- Journal of the American Chemical Society, Vol.136(20), pp.7257-7260
- Academic Unit
- Chemistry, Department of
- Publisher
- American Chemical Society
- Identifiers
- 99900547864801842
- Language
- English
- Resource Type
- Journal article