Reaction based fluorescent probes for hydrogen sulfide

Chunrong Liu; Bo Peng; Sheng Li; Chung-Min Park; A Richard Whorton; Ming Xian

doi:10.1021/ol3008183

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Reaction based fluorescent probes for hydrogen sulfide

Journal article

Open access

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Reaction based fluorescent probes for hydrogen sulfide

Chunrong Liu, Bo Peng, Sheng Li, Chung-Min Park, A Richard Whorton and Ming Xian

Organic letters, Vol.14(8), pp.2184-2187

04/20/2012

DOI: https://doi.org/10.1021/ol3008183

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https://hdl.handle.net/2376/107567

PMCID: PMC3336739

PMID: 22486842

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Abstract

Fluorescent Dyes - chemical synthesis

Hydrogen Sulfide - analysis

Fluorescent Dyes - chemistry

Sulfhydryl Compounds - chemistry

Glutathione - chemistry

Molecular Structure

Catalysis

Cysteine - chemistry

A reaction based fluorescence turn-on strategy for hydrogen sulfide (H(2)S) was developed. This strategy was based on a H(2)S-specific Michael addition-cyclization sequence. Other biological thiols such as cysteine and glutathione did not pursue the reaction and therefore did not turn on the fluorescence/consume the substrates. The probes showed good selectivity and sensitivity for hydrogen sulfide.

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Title: Reaction based fluorescent probes for hydrogen sulfide
Creators: Chunrong Liu - Department of Chemistry, Washington State University, Pullman, Washington 99164, USA
Bo Peng
Sheng Li
Chung-Min Park
A Richard Whorton
Ming Xian
Publication Details: Organic letters, Vol.14(8), pp.2184-2187
Academic Unit: Chemistry, Department of
Publisher: United States
Grant note: R01HL088559 / NHLBI NIH HHS R01 HL088559 / NHLBI NIH HHS R01 HL088559-01A2 / NHLBI NIH HHS
Identifiers: 99900547437101842
Language: English
Resource Type: Journal article