Journal article
Rearrangement of the MLL Gene in Acute Lymphoblastic and Acute Myeloid Leukemias with 11q23 Chromosomal Translocations
The New England journal of medicine, Vol.329(13), pp.909-914
09/23/1993
Handle:
https://hdl.handle.net/2376/117610
PMID: 8361504
Abstract
The molecular analysis of recurring structural abnormalities of chromosomes in human neoplasia has led to the identification of a number of genes involved in these rearrangements. Alterations in these genes are implicated in the development of malignant conditions. For example, in chronic myelogenous leukemia, the proto-oncogene ABL is translocated from chromosome 9 to the BCR gene on chromosome 22, leading to the generation of a chimeric gene and a fusion protein
1
. In lymphoid cancers, translocations frequently involve the immunoglobulin or T-cell-receptor genes, which are juxtaposed to critical oncogenes, causing their abnormal expression
2
. Recently, many of the chromosomal translocation . . .
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Details
- Title
- Rearrangement of the MLL Gene in Acute Lymphoblastic and Acute Myeloid Leukemias with 11q23 Chromosomal Translocations
- Creators
- Michael J ThirmanHeidi J GillRobert C BurnettDavid MbangkolloNorah R McCabeHirofumi KobayashiSheryl Ziemin-van der PoelYasuhiko KanekoRodman MorganAvery A SandbergR.S.K ChagantiRichard A LarsonMichelle M Le BeauManuel O DiazJanet D Rowley
- Publication Details
- The New England journal of medicine, Vol.329(13), pp.909-914
- Academic Unit
- Molecular Biosciences, School of
- Publisher
- Massachusetts Medical Society
- Identifiers
- 99900548265001842
- Language
- English
- Resource Type
- Journal article