Journal article
Recent Advances in Biosensors for Detecting Cancer-Derived Exosomes
Trends in biotechnology (Regular ed.), Vol.37(11), pp.1236-1254
11/01/2019
PMID: 31104858
Abstract
Early detection and effective treatments are two of the greatest challenges in the fight against cancer. Cancer-derived exosomes are attractive biomarkers for the early diagnosis and therapeutic response evaluation of cancer. Here, we review recent advances in biosensors for the detection of cancer-derived exosomes. We discuss the potential exosomal biomarkers of various cancers, which can be applied as indicative targets in the design of biosensors. We further describe the fabrication of exosome detection biosensors with respect to biological recognition strategies and signal transduction techniques, which involve integrated scientific and technological aspects of analytical chemistry and nanotechnology. Furthermore, future research directions and challenges in using cancer-derived exosomes for point-of-care (POC) testing are presented.
Exosomes are ideal candidates for reliable next-generation biomarkers for use in noninvasive methodologies for the early diagnosis and therapeutic response evaluation of cancer.With the development of biosensors for the detection of exosomes, individuals in resource-limited regions who previously had no access to advanced diagnostic tools can benefit and cancer therapy can also be improved, creating a promising trend for POC usage.The most recent advances in biosensors used to detect cancer-derived exosomes have focused on target choice, biological recognition strategies, and signal transduction techniques.Although various biosensors have been reported and summarized for the detection of cancer-derived exosomes, the challenges and some of the crucial issues in this field still need to be addressed before their use in clinical applications.
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Details
- Title
- Recent Advances in Biosensors for Detecting Cancer-Derived Exosomes
- Creators
- Nan Cheng - China Agricultural UniversityDan Du - Washington State UniversityXinxian Wang - China Agricultural UniversityDong Liu - Washington State UniversityWentao Xu - China Agricultural UniversityYunbo Luo - China Agricultural UniversityYuehe Lin - Washington State University
- Publication Details
- Trends in biotechnology (Regular ed.), Vol.37(11), pp.1236-1254
- Academic Unit
- School of Mechanical and Materials Engineering
- Publisher
- Elsevier Ltd
- Number of pages
- 19
- Identifiers
- 99901227640701842
- Language
- English
- Resource Type
- Journal article