Journal article
Recent Development of Hydrogen Sulfide Releasing/Stimulating Reagents and Their Potential Applications in Cancer and Glycometabolic Disorders
Frontiers in pharmacology, Vol.8, pp.664-664
09/26/2017
Handle:
https://hdl.handle.net/2376/114526
PMCID: PMC5623001
PMID: 29018341
Abstract
As an important endogenous gaseous signaling molecule, hydrogen sulfide (H
2
S) exerts various effects in the body. A variety of pathological changes, such as cancer, glycometabolic disorders, and diabetes, are associated with altered endogenous levels of H
2
S, especially decreased. Therefore, the supplement of H
2
S is of great significance for the treatment of diseases containing the above pathological changes. At present, many efforts have been made to increase the
in vivo
levels of H
2
S by administration of gaseous H
2
S, simple inorganic sulfide salts, sophisticated synthetic slow-releasing controllable H
2
S donors or materials, and using H
2
S stimulating agents. In this article, we reviewed the recent development of H
2
S releasing/stimulating reagents and their potential applications in two common pathological processes including cancer and glycometabolic disorders.
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Details
- Title
- Recent Development of Hydrogen Sulfide Releasing/Stimulating Reagents and Their Potential Applications in Cancer and Glycometabolic Disorders
- Creators
- Chun-tao Yang - Affiliated Cancer Hospital and Institute, Key Laboratory of Protein Modification and Degradation in School of Basic Medical Sciences, Guangzhou Medical UniversityLi Chen - Affiliated Cancer Hospital and Institute, Key Laboratory of Protein Modification and Degradation in School of Basic Medical Sciences, Guangzhou Medical UniversityShi Xu - Department of Chemistry, Washington State UniversityJacob J Day - Department of Chemistry, Washington State UniversityXiang Li - Affiliated Cancer Hospital and Institute, Key Laboratory of Protein Modification and Degradation in School of Basic Medical Sciences, Guangzhou Medical UniversityMing Xian - Department of Chemistry, Washington State University
- Publication Details
- Frontiers in pharmacology, Vol.8, pp.664-664
- Academic Unit
- Chemistry, Department of
- Publisher
- Frontiers Media S.A
- Grant note
- R01HL116571 / National Institutes of Health
- Identifiers
- 99900547576601842
- Language
- English
- Resource Type
- Journal article