Journal article
Recent advances in bone tissue engineering scaffolds
Trends in biotechnology (Regular ed.), Vol.30(10), pp.546-554
10/2012
Handle:
https://hdl.handle.net/2376/105443
PMCID: PMC3448860
PMID: 22939815
Abstract
Bone disorders are of significant concern due to increase in the median age of our population. Traditionally, bone grafts have been used to restore damaged bone. Synthetic biomaterials are now being used as bone graft substitutes. These biomaterials were initially selected for structural restoration based on their biomechanical properties. Later scaffolds were engineered to be bioactive or bioresorbable to enhance tissue growth. Now scaffolds are designed to induce bone formation and vascularization. These scaffolds are often porous, made of biodegradable materials that harbor different growth factors, drugs, genes, or stem cells. In this review, we highlight recent advances in bone scaffolds and discuss aspects that still need to be improved.
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Details
- Title
- Recent advances in bone tissue engineering scaffolds
- Creators
- Susmita Bose - W.M. Keck Biomedical Materials Research Lab, School of Mechanical and Materials Engineering, Washington State University, Pullman, WA 99164-2920, USA. sbose@wsu.eduMangal RoyAmit Bandyopadhyay
- Publication Details
- Trends in biotechnology (Regular ed.), Vol.30(10), pp.546-554
- Academic Unit
- Mechanical and Materials Engineering, School of
- Publisher
- England
- Grant note
- R01 EB007351 / NIBIB NIH HHS R01A1EB 007351 / NIBIB NIH HHS
- Identifiers
- 99900546563701842
- Language
- English
- Resource Type
- Journal article