Journal article
Redox chemistry and chemical biology of H2S, hydropersulfides, and derived species: Implications of their possible biological activity and utility
Free radical biology & medicine, Vol.77, pp.82-94
12/2014
Handle:
https://hdl.handle.net/2376/101330
PMCID: PMC4258476
PMID: 25229186
Abstract
Hydrogen sulfide (H2S) is an endogenously generated and putative signaling/effector molecule. Despite its numerous reported functions, the chemistry by which it elicits its functions is not understood. Moreover, recent studies allude to the existence of other sulfur species besides H2S that may play critical physiological roles. Herein, the basic chemical biology of H2S as well as other related or derived species is discussed and reviewed. This review particularly focuses on the per- and polysulfides which are likely in equilibrium with free H2S and which may be important biological effectors themselves.
[Display omitted]
•Hydrogen sulfide (H2S) is proposed to be an endogenously synthesized small-molecule signaling agent involved in a variety of physiological functions.•Many of the biological actions proposed for H2S may be due to the presence of other sulfur species such as per- and/or polysulfides.•Persulfides (RSSH) and related species have unique chemistry distinct from other biologically relevant sulfur species.•The biological utility of persulfides may be a result of their enhanced ability (compared to thiols) to serve as nucleophiles and reductants.
Metrics
11 Record Views
Details
- Title
- Redox chemistry and chemical biology of H2S, hydropersulfides, and derived species: Implications of their possible biological activity and utility
- Creators
- Katsuhiko Ono - Department of Chemistry, Sonoma State University, Rohnert Park, CA 94928, USATakaaki Akaike - Department of Environmental Health Sciences and Molecular Toxicology, Tohoku University Graduate School of Medicine, Sendai 980-8575, JapanTomohiro Sawa - Department of Environmental Health Sciences and Molecular Toxicology, Tohoku University Graduate School of Medicine, Sendai 980-8575, JapanYoshito Kumagai - Doctoral Program in Biomedical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8575, JapanDavid A Wink - Tumor Biology Section, Radiation Biology Branch, National Cancer Institute, Bethesda, MD 20892, USADean J Tantillo - Department of Chemistry, University of California, Davis, 1 Shields Avenue, Davis, CA 95616, USAAdrian J Hobbs - William Harvey Research Institute, Bart & London School of Medicine, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UKPeter Nagy - Department of Molecular Immunology and Toxicology, National Institute of Oncology, Budapest, HungaryMing Xian - Department of Chemistry, Washington State University, Pullman, WA 99164, USAJoseph Lin - Department of Biology, Sonoma State University, Rohnert Park, CA 94928, USAJon M Fukuto - Department of Chemistry, Sonoma State University, Rohnert Park, CA 94928, USA
- Publication Details
- Free radical biology & medicine, Vol.77, pp.82-94
- Academic Unit
- Chemistry, Department of
- Publisher
- Elsevier Inc
- Identifiers
- 99900546557401842
- Language
- English
- Resource Type
- Journal article