Redox interference-free bimodal paraoxon sensing enabled by an aggregation-induced emission nanozyme catalytically hydrolyzing phosphoesters specifically

Hengjia Zhu; Bangxiang Liu; Jianming Pan; Lizhang Xu; Jinjin Liu; Panwang Hu; Dan Du; Yuehe Lin; Xiangheng Niu

doi:10.1016/j.bios.2024.116756

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Redox interference-free bimodal paraoxon sensing enabled by an aggregation-induced emission nanozyme catalytically hydrolyzing phosphoesters specifically

Journal article

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Redox interference-free bimodal paraoxon sensing enabled by an aggregation-induced emission nanozyme catalytically hydrolyzing phosphoesters specifically

Hengjia Zhu, Bangxiang Liu, Jianming Pan, Lizhang Xu, Jinjin Liu, Panwang Hu, Dan Du, Yuehe Lin and Xiangheng Niu

Biosensors & bioelectronics, Vol.267, p.116756

01/01/2025

DOI: https://doi.org/10.1016/j.bios.2024.116756

PMID: 39244836

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Abstract

Biotechnology & Applied Microbiology

Chemistry

Chemistry, Analytical

Life Sciences & Biomedicine

Nanoscience & Nanotechnology

Science & Technology

Science & Technology - Other Topics

Biophysics

Electrochemistry

Physical Sciences

In view of the current serious situation of organophosphorus pesticides (OPs) residue contamination, developing rapid and accurate OPs sensors is a matter of urgency. Redox-nanozyme based colorimetric sensors have been widely researched and utilized in OPs residue determination, but overcoming the interference of external redox substances and the effect of single-signal modes on detection performance is still a challenge. Here we fabricated a Zr-based metal-organic framework (MOF) featuring specific phosphatase-like activity and strong aggregation-induced emission (AIE) fluorescence for redox interference-free bimodal pesticide sensing. In the MOF, the activity-tunable Zr4+ node offered high hydrolytic activity and affinity toward P-O containing substrates, and the rigid framework structure effectively enhanced the fluorescence emission of the ligand 1,1,2,2-tetra(4-carboxylphenyl)ethylene. The developed AIEzyme could efficiently catalyze the hydrolysis of paraoxon to yellow p-nitrophenol, which further reduced the intrinsic AIE fluorescence of AIEzyme through internal filtration effect. Thereby, a natural enzyme-free dual-mode colorimetric/fluorescence approach was established for paraoxon detection with no interference from redox substances, and a smartphone-assisted portable platform was further developed to enable the facile, rapid, and high-performance sensing of the pesticide in complex practical matrices.

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Title: Redox interference-free bimodal paraoxon sensing enabled by an aggregation-induced emission nanozyme catalytically hydrolyzing phosphoesters specifically
Creators: Hengjia Zhu - Jiangsu University
Bangxiang Liu - Jiangsu University
Jianming Pan - Jiangsu University
Lizhang Xu - Jiangsu University
Jinjin Liu - University of South China
Panwang Hu - Jiangsu University
Dan Du - Washington State University
Yuehe Lin - Washington State University
Xiangheng Niu - Jiangsu University
Publication Details: Biosensors & bioelectronics, Vol.267, p.116756
Academic Unit: School of Mechanical and Materials Engineering
Publisher: Elsevier
Number of pages: 10
Grant note: 21605061 / National Natural Sci-ence Foundation of China; National Natural Science Foundation of China (NSFC) 2023RC3168 / Science and Technology Innovation Program of Hunan Province 221RGC011 / Start-Up Research Fund of University of South China 2023JJ40534 / Natural Science Founda-tion of Hunan Province; Natural Science Foundation of Hunan Province High-Level Talent Project of Health Commission of Hunan Province
Identifiers: 99901227636901842
Language: English
Resource Type: Journal article