Regulation of primordial follicle assembly and development

Michael K Skinner

doi:10.1093/humupd/dmi020

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Regulation of primordial follicle assembly and development

Journal article

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Regulation of primordial follicle assembly and development

Michael K Skinner

Human reproduction update, Vol.11(5), pp.461-471

09/2005

DOI: https://doi.org/10.1093/humupd/dmi020

Handle:

https://hdl.handle.net/2376/113111

PMID: 16006439

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Abstract

Stem Cell Factor - metabolism

Ovarian Follicle - growth & development

Primary Ovarian Insufficiency - pathology

Glycoproteins - metabolism

Granulosa Cells - metabolism

Fibroblast Growth Factors - metabolism

Bone Morphogenetic Proteins - metabolism

Testicular Hormones - metabolism

Anti-Mullerian Hormone

Ovarian Follicle - physiology

Fibroblast Growth Factor 2 - metabolism

Fibroblast Growth Factor 7

Primary Ovarian Insufficiency - physiopathology

Ovarian Follicle - cytology

Ovarian Follicle - pathology

Interleukin-6 - metabolism

Leukemia Inhibitory Factor

Granulosa Cells - cytology

The assembly of the primordial follicles early in ovarian development and the subsequent development and transition of the primordial follicle to the primary follicle are critical processes in ovarian biology. These processes directly affect the number of oocytes available to a female throughout her reproductive life. Once the pool of primordial follicles is depleted a series of physiological changes known as menopause occur. The inappropriate coordination of these processes contributes to ovarian pathologies such as premature ovarian failure (POF) and infertility. Primordial follicle assembly and development are coordinated by locally produced paracrine and autocrine growth factors. Endocrine factors such as progesterone have also been identified that influence follicular assembly. Locally produced factors that promote the primordial to primary follicle transition include growth factors such as kit ligand (KL), leukaemia inhibitory factor (LIF), bone morphogenic proteins (BMP's), keratinocyte growth factor (KGF) and basic fibroblast growth factor (bFGF). Factors mediating both precursor theca-granulosa cell interactions and granulosa-oocyte interactions have been identified. A factor produced by preantral and antral follicles, Müllerian inhibitory substance, can act to inhibit the primordial to primary follicle transition. Observations suggest that a complex network of cell-cell interactions is required to control the primordial to primary follicle transition. Elucidation of the molecular and cellular control of primordial follicle assembly and the primordial to primary follicle transition provides therapeutic targets to regulate ovarian function and treat ovarian disease.

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Title: Regulation of primordial follicle assembly and development
Creators: Michael K Skinner - Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, WA 99164-4231, USA. Skinner@mail.wsu.edu
Publication Details: Human reproduction update, Vol.11(5), pp.461-471
Academic Unit: Biological Sciences, School of
Publisher: England
Identifiers: 99900547944301842
Language: English
Resource Type: Journal article