Journal article
Regulation of the Postsynaptic Cytoskeleton: Roles in Development, Plasticity, and Disorders
The Journal of neuroscience, Vol.30(45), pp.14937-14942
Mini-Symposium
11/10/2010
Handle:
https://hdl.handle.net/2376/109793
PMCID: PMC3074493
PMID: 21068295
Abstract
The small size of dendritic spines belies the elaborate role they play in excitatory synaptic transmission and ultimately complex behaviors. The cytoskeletal architecture of the spine is predominately composed of actin filaments. These filaments, which at first glance might appear simple, are also surprisingly complex. They dynamically assemble into different structures and serve as a platform for orchestrating the elaborate responses of the spine during experience-dependent plasticity. This mini-symposium review will feature ongoing research into how spines are regulated by actin-signaling pathways during development and plasticity. It will also highlight evolving studies into how disruptions to these pathways might be functionally coupled to congenital disorders such as mental retardation.
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Details
- Title
- Regulation of the Postsynaptic Cytoskeleton: Roles in Development, Plasticity, and Disorders
- Creators
- Tatyana Svitkina - Department of Biology, The University of Pennsylvania, Philadelphia, Pennsylvania 19104Wan-Hsin Lin - Department of Biological SciencesDonna J Webb - Department of Biological SciencesRyohei Yasuda - Howard Hughes Medical InstituteGary A Wayman - Program in Neuroscience andLinda Van Aelst - Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724Scott H Soderling - Departments of Neurobiology and
- Publication Details
- The Journal of neuroscience, Vol.30(45), pp.14937-14942
- Academic Unit
- Integrative Physiology and Neuroscience, Department of
- Series
- Mini-Symposium
- Publisher
- Society for Neuroscience
- Identifiers
- 99900547104801842
- Language
- English
- Resource Type
- Journal article